Аннотация:
Novel spiroandrostene-17,6'-[1,3,4]thiadiazines obtained by synthesis from 16β,17β-epoxy-17-isopregn-5-en-3β-ol-20-one and N-aryl-2-hydrazino-2-thioxoacetamide efficiently inhibited the release of Epstein–Barr virus from cells carrying the virus in culture. Other studied steroids, such as Spirolactone, Digitonin, Diosgenin, and Hecogenin were inactive. DMSO alone was found to inhibit the virus release, as well, likely, because of changing properties of the cell membranes. The novel steroids, Spironolactone and most analogues display no or low cell toxicity while Digitonin produced a significant toxic effect.
Образец цитирования:
A. G. Malykh, A. R. Pavlov, A. V. Komkov, Yu. A. Volkova, L. G. Menchikov, I. V. Zavarzin, “New synthetic corticosteroids inhibit Epstein–Barr virus release”, Mendeleev Commun., 31:5 (2021), 667–669
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1017
https://www.mathnet.ru/rus/mendc/v31/i5/p667
Эта публикация цитируется в следующих 5 статьяx:
Alexander V. Komkov, Leonid G. Menchikov, Andrey S. Dmitrenok, Natalya G. Kolotyrkina, Igor V. Zavarzin, “3-Spiroandrostene-substituted 1,3,4-thiadiazolines”, Chem Heterocycl Comp, 60:3-4 (2024), 190
A. V. Komkov, L. G. Menchikov, A. S. Dmitrenok, N. G. Kolotyrkina, I. V. Zavarzin, “Unusual reaction of 16α,17α-epoxypregn-5-en-20-one derivative with hydroxylamine”, Russ Chem Bull, 73:2 (2024), 458
Svetlana K. Vorontsova, Alexander M. Scherbakov, Mikhail E. Minyaev, Leonid G. Menchikov, Igor V. Zavarzin, “The synthesis of furazano- and thiadiazolopyrazine steroids and their antiproliferative activity”, Chem Heterocycl Comp, 60:3-4 (2024), 205
Alexander V. Komkov, Leonid G. Menchikov, Andrey S. Dmitrenok, Alexander M. Scherbakov, Diana I. Salnikova, Inna S. Levina, Igor V. Zavarzin, “A new approach to the synthesis of 17-pyrazolylandrostane”, Chem Heterocycl Comp, 59:8 (2023), 554
A. V. Komkov, L. G. Menchikov, A. S. Dmitrenok, I. V. Zavarzin, “Synthesis of androstane derivatives fused with polyheterocycles at the D ring”, Mendeleev Commun., 33:6 (2023), 782–783
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