Study of the derivatives of 1-adamantane carboxylic acid to induced platelet aggregation human in vitro

The study of newly synthesized derivatives of 1-adamantane carboxylic acid anilide, 1-adamantanecarboxylic acid (N-adamantyl-1-carboxamide) bromanilide1-adamantanecarboxylic acid (N-(4-bromophenyl) adamantyl-1-carboxamide) on platelet aggregation induced of human in vitro is implemented. A significant effect on platelet aggregation anilide 1-adamantane carboxylic acid, 4-bromanilid 1-adamantanecarboxylic acid observed a tendency to increase its intensity. The ability to affect platelet aggregation correlates with the presence of bromine in the benzene ring. Ascending effect on aggregation can be positioned in a number of investigated solvents: acetone, 2-propanol, ethanol, methanol, dimethylsulfoxide.