Osmotic lysis of vesicles in the presence of transmembrane potential difference

The free energy of vesicle stretched membrane, on membrane which has transmembrane potential difference and cylindrical pore, was determined. It is shown that, the presence of transmembrane potential difference makes the formation of pore easier. Critical expansion of membrane, pressure drop and difference of osmotic active substance, in the presence of which pore is forming, sharply reduced. It is shown that minimal radius of pore does not depend on transmembrane potential difference.