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This article is cited in 5 scientific papers (total in 5 papers)
REVIEWS OF TOPICAL PROBLEMS
Energetics and stochastic dynamics of intraneuron transport
Yu. M. Romanovskya, V. P. Trifonenkovb a Lomonosov Moscow State University, Faculty of Physics
b National Engineering Physics Institute "MEPhI", Moscow
Abstract:
Walking molecular motors performing various functions in living cells are reviewed, including kinesin, myosin V, and dynein. These motors ensure the transport of neuromediators in neurons and are therefore crucial for interaction among the hundred billion brain cells. Functional schemes based on these motors are presented, and corresponding mathematical models are constructed as systems of two coupled FitzHugh–Nagumo equations. However, polynomials describing the moments of force are of high order and nearly N-shaped. Model parameters are determined from motor functional schemes that are based on observed data from X-ray structural analysis, cryogenic electron microscopy, laser tweezer measurements, and fast point marker-based videomicroscopy. Basic data on neuron energetics are summarized.
Received: October 12, 2015 Revised: November 11, 2015 Accepted: November 12, 2015
Citation:
Yu. M. Romanovsky, V. P. Trifonenkov, “Energetics and stochastic dynamics of intraneuron transport”, UFN, 186:2 (2016), 125–145; Phys. Usp., 59:2 (2016), 121–140
Linking options:
https://www.mathnet.ru/eng/ufn5427 https://www.mathnet.ru/eng/ufn/v186/i2/p125
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