What problems of physics and astrophysics seem now to be especially important and interesting (thirty years later, already on the verge of XXI century)?

About thirty years ago, the author published a paper [1] under the same title which, mainly educational in its nature, aimed primarily at widening the scientific horizons of the young generation of physicists. For this purpose, a list of the top agenda problems of the day was given and commented on, admittedly subjective and unavoidably inexhaustive and limited (one cannot do the impossible, after all). In the author's later articles, additions both to the list itself and the comments were made (see [2] for the latest version). In the present paper the author takes on an end-of-the-century perspective in addressing this theme once again.