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Uspekhi Fizicheskikh Nauk, 2024, Volume 194, Number 11, Pages 1130–1145
DOI: https://doi.org/10.3367/UFNr.2024.07.039720 (Mi ufn15872) 		 
55th ANNIVERSARY OF THE INSTITUTE OF SPECTROSCOPY OF THE RUSSIAN ACADEMY OF SCIENCES (ISAN). REVIEWS OF TOPICAL PROBLEMS

Optical methods for detection of single biomolecules: visualization, sensorics, sequencing of DNA molecules

P. N. Melentieva, A. S. Kalmykova, A. S. Gritchenkoa, M. P. Shemetevaa, A. M. Safonovaa, M. S. Markova, V. I. Balykina, A. S. Bukatinb, N. V. Vaulinb, D. A. Belovb, A. A. Evstrapovb, D. A. Baklykovc, A. V. Andriyashc, A. A. Barbashevad, A. K. Kugukd, V. V. Ryzhkovd, I. A. Rodionovd, D. S. Kudryavtseve, V. A. Mozhaevae, L. V. Sone, V. I. Tsetline, B. N. Khlebtsovf, M. S. Kobzevg, Yu. O. Kuznetsovag, B. T. Sharipovg, A. S. Yashking, Ya. I. Alekseevbg

a Institute of Spectroscopy, Russian Academy of Sciences, Troitsk, Moscow
b Institute for Analytical Instrumentation, Russian Academy of Sciences, St. Petersburg
c Dukhov Research Institute of Automatic, Moscow
d Bauman Moscow State Technical University
e Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
f Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Center, Russian Academy of Sciences, Saratov
g Sintol Ltd., Moscow
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DOI: https://doi.org/10.3367/UFNr.2024.07.039720
Abstract: A brief overview of the state of the art in optical methods for detecting a single molecule in biomedical applications is presented. It is shown that the registration of fluorescence of single dye molecules covalently bound to antibodies (biomolecules), together with the use of modern nanophotonics methods, can be used to solve various problems in biology and medicine: visualization of biomolecules, toxins, and virus particles; determination of extremely low concentrations of analytes directly in a sample without using methods for increasing the analyte concentration; and optical single-molecule sequencing of DNA molecules. The existing physical limitations of the methods of optical detection and counting of single molecules and their impact on solving existing problems in biology, medicine, and genetics are discussed.
Funding agency Grant number
Ministry of Science and Higher Education of the Russian Federation FFUU-2024-0003
075-15-2021-1057
Russian Science Foundation 23-42-00049
The research was carried out within the framework of the FFUU-2024-003 project of the Institute of Spectroscopy of the Russian Academy of Sciences and with the financial support from the Russian Science Foundation, project no. 23-42-00049. Also the research was carried out within the framework of the research program of the Ministry of Science and Higher Education of the Russian Federation (project no. 075-15-2021-1057, lead organization—Institute for Analytical Instrumentation of the Russian Academy of Sciences).
Received: March 13, 2024
Revised: July 16, 2024
Accepted: July 17, 2024
English version:
Physics–Uspekhi, 2024, Volume 67, Issue 11, Pages 1069–1083
DOI: https://doi.org/10.3367/UFNe.2024.07.039720
Bibliographic databases:
Document Type: Article
PACS: 07.60.-j, 32.50.+d, 87.64.-t
Language: Russian
Citation: P. N. Melentiev, A. S. Kalmykov, A. S. Gritchenko, M. P. Shemeteva, A. M. Safonova, M. S. Markov, V. I. Balykin, A. S. Bukatin, N. V. Vaulin, D. A. Belov, A. A. Evstrapov, D. A. Baklykov, A. V. Andriyash, A. A. Barbasheva, A. K. Kuguk, V. V. Ryzhkov, I. A. Rodionov, D. S. Kudryavtsev, V. A. Mozhaeva, L. V. Son, V. I. Tsetlin, B. N. Khlebtsov, M. S. Kobzev, Yu. O. Kuznetsova, B. T. Sharipov, A. S. Yashkin, Ya. I. Alekseev, “Optical methods for detection of single biomolecules: visualization, sensorics, sequencing of DNA molecules”, UFN, 194:11 (2024), 1130–1145; Phys. Usp., 67:11 (2024), 1069–1083
Citation in format AMSBIB
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\by P.~N.~Melentiev, A.~S.~Kalmykov, A.~S.~Gritchenko, M.~P.~Shemeteva, A.~M.~Safonova, M.~S.~Markov, V.~I.~Balykin, A.~S.~Bukatin, N.~V.~Vaulin, D.~A.~Belov, A.~A.~Evstrapov, D.~A.~Baklykov, A.~V.~Andriyash, A.~A.~Barbasheva, A.~K.~Kuguk, V.~V.~Ryzhkov, I.~A.~Rodionov, D.~S.~Kudryavtsev, V.~A.~Mozhaeva, L.~V.~Son, V.~I.~Tsetlin, B.~N.~Khlebtsov, M.~S.~Kobzev, Yu.~O.~Kuznetsova, B.~T.~Sharipov, A.~S.~Yashkin, Ya.~I.~Alekseev
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