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This article is cited in 5 scientific papers (total in 5 papers)
Nonparametric estimation of effective doses at quantal response
M. S. Tikhov Lobachevsky State University of Nizhni Novgorod,
Gagarin avenue, 23, 603950, Nizhni Novgorod, Russia
Abstract:
For the quantal response model we propose a new direct method for nonparametric estimation of the effective dose level $ED_{100\lambda}$ ($0 < \lambda < 1$). This method yields a simple and reliable monotone estimate of the effective dose level curve $\lambda\to ED_{100\lambda}$ and is appealing to users of conventional smoothing methods of kernel estimates. Moreover, it is computationally very efficient, because it does not require a numerical inversion of the estimate of the quantile dose response curve. We prove asymptotic normality of this new estimator and compare it with the DNP-estimator.
Keywords:
binary response model, effective dose level, nonparametric estimate.
Received: 16.02.2012
Citation:
M. S. Tikhov, “Nonparametric estimation of effective doses at quantal response”, Ufa Math. J., 5:2 (2013), 94–108
Linking options:
https://www.mathnet.ru/eng/ufa201https://doi.org/10.13108/2013-5-2-94 https://www.mathnet.ru/eng/ufa/v5/i2/p94
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Abstract page: | 2936 | Russian version PDF: | 2707 | English version PDF: | 15 | References: | 2558 | First page: | 2 |
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