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Sibirskii Zhurnal Industrial'noi Matematiki, 2023, Volume 26, Number 3, Pages 142–153
DOI: https://doi.org/10.33048/SIBJIM.2023.26.311 (Mi sjim1253) 		 
The central regulatory circuit of the morphogenesis system drosophila mechanoreceptors: mutation effects

D. P. Furmanab, T. A. Bukharinaab, V. P. Golubyatnikovc

a Federal Research Center Institute of Cytology and Genetics SB RAS, pr. Lavrentieva 10, Novosibirsk 630090, Russia
b Novosibirsk State University, ul. Pirogova 1, Novosibirsk 630090, Russia
c Institute of Mathematics named after S. L. Sobolev SB RAS, pr. Acad. Koptyuga 4, Novosibirsk 630090, Russia
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DOI: https://doi.org/10.33048/SIBJIM.2023.26.311
Abstract: A mathematical model of the functioning of the central regulatory circuit of gene networks of morphogenesis of drosophila mechanoreceptors is described, taking into account mutations of its genes. Computational experiments have been carried out showing the presence of a hierarchy of effects of CRK gene mutations on the production of ASC proteins.
Keywords: central regulatory circuit, gene network, mathematical model, parameter identification, computer modeling, fruit fly, achaete-scute complex, mutations.
Funding agency Grant number
Ministry of Science and Higher Education of the Russian Federation FWNR-2022-0020
FWNF-2022-0009
Received: 09.02.2023
Revised: 29.03.2023
Accepted: 27.04.2023
English version:
Journal of Applied and Industrial Mathematics, 2023, Volume 17, Issue 3, Pages 535–543
DOI: https://doi.org/10.1134/S1990478923030079
Document Type: Article
UDC: 517.958:539.3
Language: Russian
Citation: D. P. Furman, T. A. Bukharina, V. P. Golubyatnikov, “The central regulatory circuit of the morphogenesis system drosophila mechanoreceptors: mutation effects”, Sib. Zh. Ind. Mat., 26:3 (2023), 142–153; J. Appl. Industr. Math., 17:3 (2023), 535–543
Citation in format AMSBIB
\Bibitem{FurBukGol23}
\by D.~P.~Furman, T.~A.~Bukharina, V.~P.~Golubyatnikov
\paper The central regulatory circuit of the morphogenesis system drosophila mechanoreceptors: mutation effects
\jour Sib. Zh. Ind. Mat.
\yr 2023
\vol 26
\issue 3
\pages 142--153
\mathnet{http://mi.mathnet.ru/sjim1253}
\crossref{https://doi.org/10.33048/SIBJIM.2023.26.311}
\transl
\jour J. Appl. Industr. Math.
\yr 2023
\vol 17
\issue 3
\pages 535--543
\crossref{https://doi.org/10.1134/S1990478923030079}
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