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Sibirskii Zhurnal Industrial'noi Matematiki, 2020, Volume 23, Number 2, Pages 41–50
DOI: https://doi.org/10.33048/SIBJIM.2020.23.203 (Mi sjim1086) 		 
This article is cited in 8 scientific papers (total in 8 papers)

Mathematical and numerical models of the central regulatory circuit of the morphogenesis system of Drosophila

T. A. Bukharinaa, A. A. Akinshinb, V. P. Golubyatnikovcb, D. P. Furmanac

a Federal Research Center Institute of Cytology and Genetics SB RAS, pr. Akad. Lavrentieva 10, Novosibirsk 630090, Russia
b Sobolev Institute of Mathematics SB RAS, pr. Akad. Koptyuga 4, Novosibirsk 630090, Russia
c Novosibirsk State University, ul. Pirogova 1, Novosibirsk 630090, Russia
Full-text PDF (847 kB) Citations (8)
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DOI: https://doi.org/10.33048/SIBJIM.2020.23.203
Abstract: The results are presented of mathematical and computer simulation of the functioning of the central regulatory circuit (CRC) which is the system integrator of gene networks of morphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented by the complex of achaete-scute ( AS-C) genes, the main genes of the mechanoreceptor morphogenesis. The content level of the proteins encoded by the AS-C genes is a determining factor for initiating the development of a mechanoreceptor. We carried out a comparative study of the CRC behavior under normal conditions and in the presence of mutational changes in the achaete-scute complex. The results of simulation are in good accord with the available biological data.
Keywords: nonlinear dynamical system, mathematical model, numerical simulation, gene network, Drosophila, central regulatory circuit, mechanoreceptor, achaete-scute complex, mutation.
Funding agency Grant number
Russian Foundation for Basic Research 18-01-00057_a
Siberian Branch of Russian Academy of Sciences 0324-2018-0021
0314-2018-0011
The authors are sincerely grateful to the referee whose criticisms contributed to a significant improvement of the text of the article.
Received: 02.12.2019
Revised: 15.01.2020
Accepted: 09.04.2020
English version:
Journal of Applied and Industrial Mathematics, 2020, Volume 14, Issue 2, Pages 249–255
DOI: https://doi.org/10.1134/S1990478920020040
Bibliographic databases:
Document Type: Article
UDC: 514.745.82
Language: Russian
Citation: T. A. Bukharina, A. A. Akinshin, V. P. Golubyatnikov, D. P. Furman, “Mathematical and numerical models of the central regulatory circuit of the morphogenesis system of Drosophila”, Sib. Zh. Ind. Mat., 23:2 (2020), 41–50; J. Appl. Industr. Math., 14:2 (2020), 249–255
Citation in format AMSBIB
\Bibitem{BukAkiGol20}
\by T.~A.~Bukharina, A.~A.~Akinshin, V.~P.~Golubyatnikov, D.~P.~Furman
\paper Mathematical and numerical models of the central regulatory circuit of the morphogenesis system of Drosophila
\jour Sib. Zh. Ind. Mat.
\yr 2020
\vol 23
\issue 2
\pages 41--50
\mathnet{http://mi.mathnet.ru/sjim1086}
\crossref{https://doi.org/10.33048/SIBJIM.2020.23.203}
\elib{https://elibrary.ru/item.asp?id=45445963}
\transl
\jour J. Appl. Industr. Math.
\yr 2020
\vol 14
\issue 2
\pages 249--255
\crossref{https://doi.org/10.1134/S1990478920020040}
\scopus{https://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85087767751}
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    • This publication is cited in the following 8 articles:
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    		Сибирский журнал индустриальной математики
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