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This article is cited in 18 scientific papers (total in 18 papers)
The structure and properties of complexes simulating molecular recognition
O. A. Raevsky Institute of Physiologically Active Compounds of the USSR Academy of Sciences, Chernogolovka
Abstract:
The main trends in the evolution of the concept of molecular recognition are examined. The possibility of using thermodynamic parameters for a quantitative characterisation of recognition and the effect of their relationships on the degree of recognition are analysed. Complexes, containing one or more hydrogen bonds, between macrocyclic compounds and metal ions, alkyl and alkylammonium derivatives, and various anions are characterised in detail as model compounds. The problem of competitive complexation in an aqueous medium is discussed. The role of computer-aided simulation of molecular recognition in applied studies relating to the design of biologically active compounds is assessed. The suitability of such a combination of experimental and theoretical studies, in which the models for molecular recognition could be constantly improved, is noted. 224 references.
Citation:
O. A. Raevsky, “The structure and properties of complexes simulating molecular recognition”, Usp. Khim., 59:3 (1990), 375–400; Russian Chem. Reviews, 59:3 (1990), 219–233
Linking options:
https://www.mathnet.ru/eng/rcr799https://doi.org/10.1070/RC1990v059n03ABEH003521 https://www.mathnet.ru/eng/rcr/v59/i3/p375
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