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Russian Chemical Reviews, 2022, Volume 91, Issue 6, RCR5041
DOI: https://doi.org/10.1070/RCR5041 		 
This article is cited in 10 scientific papers (total in 10 papers)

Small synthetic molecules with antiglycation activity. Structure–activity relationship

K. V. Savateeva, A. A. Spasovb, V. L. Rusinova

a Ural Federal University named after the First President of Russia B. N. Yeltsin, Ekaterinburg
b Volgograd State Medical University
English full-text Citations (10)
DOI: https://doi.org/10.1070/RCR5041
Abstract: The accumulation of advanced glycation end products (AGEs) is currently considered as one of the key factors in aging processes, the pathogenesis of late complications of diabetes mellitus, cancer and neurodegenerative diseases. This review is devoted to small synthetic molecules with antiglycation activity, i.e., compounds with the ability to inhibit AGE formation. Molecules with antiglycation activity in the low micromolar range ($<$10 $\mu$M), primarily fused heterocyclic systems containing oxygen or nitrogen as heteroatoms and (thio)ureas, have been discovered to date. The known scaffolds with antiglycation activity are analyzed, structural modifications to enhance antiglycation abilities are highlighted and the structure–activity relationships are discussed.
The bibliography includes 125 references.
Keywords: diabetes mellitus, advanced glycation end products, antiglycation activity, structure-activity relationship.
Funding agency Grant number
Ministry of Education and Science of the Russian Federation 075-15-2020-777
This work was financially supported within the framework of the grant agreement as government subsidies from the Federal budget in accordance with paragraph 4 of article 78.1 of the Budget Code of the Russian Federation (Moscow, 1 October 2020, No. 075-15-2020-777).
Received: 29.11.2021
Russian version:
Uspekhi Khimii, 2022, Volume 91, Issue 6, RCR5041
DOI: https://doi.org/10.1070/RCR5041
Bibliographic databases:
Document Type: Article
Language: English
Original paper language: Russian
Citation: K. V. Savateev, A. A. Spasov, V. L. Rusinov, “Small synthetic molecules with antiglycation activity. Structure–activity relationship”, Usp. Khim., 91:6 (2022), RCR5041; Russian Chem. Reviews, 91:6 (2022), RCR5041
Citation in format AMSBIB
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\paper Small synthetic molecules with antiglycation activity. Structure--activity relationship
\jour Usp. Khim.
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\vol 91
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\papernumber RCR5041
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    • This publication is cited in the following 10 articles:
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