Abstract:
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and treatment of malignant neoplasms. The development of scaffold proteins has significantly simplified the design of targeting agents with desirable properties. This review comprehensively describes the key aspects of the design of radionuclide compounds, including classification of radionuclides, methodology for their attachment to targeting agents and characteristics of these agents that affect their behaviour in the body. Various targeting molecules are compared in terms of their ability to specifically find malignant foci in the body. The most recent achievements of cancer theranostics that aim at increasing the selectivity of antitumour effect are described, such as the fusion of targeting scaffold proteins with the albumin-binding domain and pretargeting. Special attention is paid to the creation of targeted radionanomaterials. Advantages and disadvantages of different strategies are analyzed and approaches for improving the delivery to tumours and for minimizing the undesirable impact on healthy organs and tissues are proposed. Particular emphasis is placed on the results of studies published in 2020–2021 that have not yet been covered by reviews.
The bibliography includes 191 references.
This publication is cited in the following 36 articles:
Maryam Oroujeni, Matilda Carlqvist, Eva Ryer, Anna Orlova, Vladimir Tolmachev, Fredrik Y. Frejd, EJNMMI radiopharm. chem., 9:1 (2024)
Maria Larkina, Ruslan Varvashenya, Feruza Yuldasheva, Evgenii Plotnikov, Ekaterina Bezverkhniaia, Maria Tretyakova, Roman Zelchan, Alexey Schulga, Elena Konovalova, Anzhelika Vorobyeva, Mikhail Belousov, Anna Orlova, Vladimir Tolmachev, Sergey Deyev, Mol. Pharmaceutics, 21:4 (2024), 1919
A. A. Rempel, O. V. Ovchinnikov, I. A. Weinstein, S. V. Rempel', Yu. V. Kuznetsova, A. V. Naumov, M. S. Smirnov, I. Yu. Eremchev, A. S. Vokhmintsev, S. S. Savchenko, Russian Chem. Reviews, 93:4 (2024), RCR5114
O. N. Shilova, E. S. Shilov, S. M. Deyev, Russian Chem. Reviews, 93:6 (2024), RCR5128
V. I. Chernov, Vestnik Rossijskoj akademii nauk, 94:1 (2024), 66
M. V. Filimonova, D. D. Kolmanovich, G. V. Tikhonowski, D. S. Petrunya, P. A. Kotelnikova, A. A. Shitova, O. V. Soldatova, A. S. Filimonov, V. A. Rybachuk, A. O. Kosachenko, K. A. Nikolaev, G. A. Demyashkin, A. A. Popov, M. S. Savinov, A. L. Popov, I. V. Zelepukin, A. A. Lipengolts, K. E. Shpakova, A. V. Kabashin, S. N. Koryakin, S. M. Deyev, I. N. Zavestovskaya, Dokl Biochem Biophys, 516:1 (2024), 111
E. I. Shramova, S. M. Deyev, G. M. Proshkina, Acta Naturae, 16:2 (2024), 72
Roman Zelchan, Vladimir Chernov, Anna Medvedeva, Anastasia Rybina, Olga Bragina, Elizaveta Mishina, Mariia Larkina, Ruslan Varvashenya, Anastasia Fominykh, Alexey Schulga, Elena Konovalova, Anzhelika Vorobyeva, Anna Orlova, Liubov Tashireva, Sergey M. Deyev, Vladimir Tolmachev, Cancers, 16:16 (2024), 2815
M. V. Filimonova, D. D. Kolmanovich, G. V. Tikhonowski, D. S. Petrunya, P. A. Kotelnikova, A. A. Shitova, O. V. Soldatova, A. S. Filimonov, V. A. Rybachuk, A. O. Kosachenko, K. A. Nikolaev, G. A. Demyashkin, A. A. Popov, M. S. Savinov, A. L. Popov, I. V. Zelepukin, A. A. Lipengolts, K. E. Shpakova, A. V. Kabashin, S. N. Koryakin, S. M. Deyev, I. N. Zavestovskaya, Doklady Rossijskoj akademii nauk. Nauki o žizni, 516:1 (2024)
Y. V. Khramtsov, A. V. Ulasov, T. N. Lupanova, G. P. Georgiev, A. S. Sobolev, Doklady Rossijskoj akademii nauk. Nauki o žizni, 515:1 (2024), 45
O. D. Bragina, L. A. Tashireva, D. M. Loos, S. V. Vtorushin, A. A. Shulga, E. N. Konovalova, M. E. Borodina, V. I. Chernov, V. M. Tolmachev, S. M. Deyev, Acta Naturae, 16:2 (2024), 22
M. V. Novoselova, E. I. Shramova, O. V. Sergeeva, E. Y. Shcherbinina, S. V. Perevoschikov, P. Melnikov, O. Yu. Griaznova, I. S. Sergeev, E. V. Konovalova, A. A. Schulga, G. M. Proshkina, T. S. Zatsepin, S. M. Deyev, D. A. Gorin, Nanomedicine: Nanotechnology, Biology and Medicine, 47 (2023), 102612
R. S. Kalinin, V. O. Shipunova, Y. P. Rubtsov, V. M. Ukrainskay, A. Schulga, E. V. Konovalova, D. V. Volkov, I. A. Yaroshevich, A. M. Moysenovich, A. A. Belogurov, G. B. Telegin, A. S. Chernov, M. A. Maschan, S. S. Terekhov, V. D. Knorre, E. Khurs, N. V. Gnuchev, A. G. Gabibov, S. M. Deyev, Dokl. Biochem. Biophys., 508:1 (2023), 17
Y. V. Khramtsov, A. V. Ulasov, T. N. Lupanova, T. A. Slastnikova, A. A. Rosenkranz, E. S. Bunin, G. P. Georgiev, A. S. Sobolev, Pharmaceutics, 16:1 (2023), 4
I. V. Balalaeva, L. V. Krylova, M. A. Karpova, A. A. Shulga, E. V. Konovalova, E. L. Gurev, S. M. Deev, Doklady Rossiiskoi akademii nauk. Nauki o zhizni, 508:1 (2023), 48
R. S. Kalinin, A. G. Gabibov, N. V. Gnuchev, E. N. Khurs, V. D. Knorre, S. S. Terekhov, M. A. Maschan, A. S. Chernov, G. B. Telegin, A. A. Belogurov, A. M. Moisenovich, I. A. Yaroshevich, D. V. Volkov, E. V. Konovalova, A. A. Shulga, V. M. Ukrainskaya, Yu. P. Rubtsov, V. O. Shipunova, S. M. Deev, Doklady Rossiiskoi akademii nauk. Nauki o zhizni, 510:1 (2023), 231
E. I. Shramova, G. M. Proshkina, S. M. Deev, Biologicheskie membrany Zhurnal membrannoi i kletochnoi biologii, 40:1 (2023), 66
Y. V. Khramtsov, A. V. Ulasov, T. N. Lupanova, G. P. Georgiev, A. S. Sobolev, Dokl. Biochem. Biophys., 513:S1 (2023), S60
Yu. V. Khramtsov, A. V. Ulasov, T. A. Slastnikova, A. A. Rosenkranz, T. N. Lupanova, G. P. Georgiev, A. S. Sobolev, Pharmaceutics, 15:12 (2023), 2687
Citation in format AMSBIB
Contact us: