|
This article is cited in 17 scientific papers (total in 17 papers)
Molecular foundations of COVID-19 pathogenesis
F. N. Novikova, V. S. Stroylova, I. Svitankoab, V. E. Nebolsinc a N.D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences
b National Research University "Higher School of Economics", Moscow
c LLC «PHARMENTERPRISES», Moscow
Abstract:
The review summarizes the publications, available at the time it was written, addressing the chemical and biological processes that occur in the human body upon exposure to coronaviruses, in particular SARS-CoV-2. The mechanisms of viral particle entry into the cell, viral replication and impact on the immune system and on oxygen transport system are considered. The causes behind complications of the viral infection, such as vasculitis, thrombosis, cytokine storm and lung fibrosis, are discussed. The latest research in the field of small molecule medications to counteract the virus is surveyed. Molecular targets and possible vectors to exploit them are considered. The review is primarily written for specialists who want to understand the chains of activation, replication, action and inhibition of SARS-CoV-2. Due to the short period of such studies, the data on complexes of small molecule compounds with possible protein targets are not numerous, but they will be useful in the search and synthesis of new potentially effective drugs.
The bibliography includes 144 references.
Keywords:
SARS-COV-2, COVID-19, coronavirus infection, antiviral drugs, molecular modelling.
Received: 01.05.2020
Citation:
F. N. Novikov, V. S. Stroylov, I. Svitanko, V. E. Nebolsin, “Molecular foundations of COVID-19 pathogenesis”, Usp. Khim., 89:8 (2020), 858–878; Russian Chem. Reviews, 89:8 (2020), 858–878
Linking options:
https://www.mathnet.ru/eng/rcr4305https://doi.org/10.1070/RCR4961 https://www.mathnet.ru/eng/rcr/v89/i8/p858
|
Statistics & downloads: |
Abstract page: | 167 |
|