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This article is cited in 17 scientific papers (total in 17 papers)
Main trends in the design of semi-synthetic antibiotics of a new generation
E. N. Olsufyevaa, V. S. Yankovskayab a G. F. Gause Institute of New Antibiotics, Moscow
b Russian State Agrarian University - Moscow Agricultural Academy after K.A. Timiryazev, Moscow
Abstract:
This review summarizes main advances achieved by Russian researchers in the synthesis and characterization of semi-synthetic antibiotics of a new generation in the period 2004 to 2019. The following classes of compounds are considered as the basis for modification: polycyclic antibacterial glycopeptides of the vancomycin group, classical macrolides, antifungal polyene macrolides, the antitumour antibiotic olivomycin A, antitumour anthracyclines and broad-spectrum antibiotics, in particular, oligomycin A, heliomycin and some other. Main trends in the design of modern anti-infective and antitumour agents over this period are considered in relation to original natural antibiotics, which have been independently discovered by Russian researchers. It is shown that hybrid structures of a new type can, in principle, be synthesized based on glycopeptides, macrolides and other antibiotics, including heterodimers containing a new benzoxaborole pharmacophore. The review addresses the influence of the length of the spacer between two antibiotic molecules on the biological activity of hybrid structures. A combination of genetic engineering techniques and methods of organic synthesis is shown to be useful for the design of new potent antifungal antibiotics based on polyenes of the amphotericin B group. Many new semi-synthetic analogues exhibit important biological properties, such as a broad spectrum of activity and low toxicity. Emphasis is given to certain aspects related to investigation of a broad range of biological activity and mechanisms of action of new derivatives.
Bibliography — 101 references.
Received: 10.04.2019
Citation:
E. N. Olsufyeva, V. S. Yankovskaya, “Main trends in the design of semi-synthetic antibiotics of a new generation”, Usp. Khim., 89:3 (2020), 339–378; Russian Chem. Reviews, 89:3 (2020), 339–378
Linking options:
https://www.mathnet.ru/eng/rcr4287https://doi.org/10.1070/RCR4892 https://www.mathnet.ru/eng/rcr/v89/i3/p339
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