Abstract:
This review summarizes main advances achieved by Russian researchers in the synthesis and characterization of semi-synthetic antibiotics of a new generation in the period 2004 to 2019. The following classes of compounds are considered as the basis for modification: polycyclic antibacterial glycopeptides of the vancomycin group, classical macrolides, antifungal polyene macrolides, the antitumour antibiotic olivomycin A, antitumour anthracyclines and broad-spectrum antibiotics, in particular, oligomycin A, heliomycin and some other. Main trends in the design of modern anti-infective and antitumour agents over this period are considered in relation to original natural antibiotics, which have been independently discovered by Russian researchers. It is shown that hybrid structures of a new type can, in principle, be synthesized based on glycopeptides, macrolides and other antibiotics, including heterodimers containing a new benzoxaborole pharmacophore. The review addresses the influence of the length of the spacer between two antibiotic molecules on the biological activity of hybrid structures. A combination of genetic engineering techniques and methods of organic synthesis is shown to be useful for the design of new potent antifungal antibiotics based on polyenes of the amphotericin B group. Many new semi-synthetic analogues exhibit important biological properties, such as a broad spectrum of activity and low toxicity. Emphasis is given to certain aspects related to investigation of a broad range of biological activity and mechanisms of action of new derivatives.
Bibliography — 101 references.
Citation:
E. N. Olsufyeva, V. S. Yankovskaya, “Main trends in the design of semi-synthetic antibiotics of a new generation”, Russian Chem. Reviews, 89:3 (2020), 339–378
\Bibitem{OlsYan20}
\by E.~N.~Olsufyeva, V.~S.~Yankovskaya
\paper Main trends in the design of semi-synthetic antibiotics of a new generation
\jour Russian Chem. Reviews
\yr 2020
\vol 89
\issue 3
\pages 339--378
\mathnet{http://mi.mathnet.ru/eng/rcr4287}
\crossref{https://doi.org/10.1070/RCR4892}
\adsnasa{https://adsabs.harvard.edu/cgi-bin/bib_query?2020RuCRv..89..339O}
\isi{https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Publons&SrcAuth=Publons_CEL&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=000518759400004}
\elib{https://elibrary.ru/item.asp?id=43271609}
\scopus{https://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85085096467}
Linking options:
https://www.mathnet.ru/eng/rcr4287
https://doi.org/10.1070/RCR4892
https://www.mathnet.ru/eng/rcr/v89/i3/p339
This publication is cited in the following 20 articles: