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Russian Chemical Reviews, 2018, Volume 87, Issue 12, Pages 1206–1225
DOI: https://doi.org/10.1070/RCR4841 (Mi rcr4236) 		 
This article is cited in 21 scientific papers (total in 21 papers)

Recent advances in antifungal drug discovery based on polyene macrolide antibiotics

O. A. Omelchukab, A. N. Tevyashovaab, A. E. Shchekotikhinab

a G. F. Gause Institute of New Antibiotics, Moscow
b D. Mendeleev University of Chemical Technology of Russia, Moscow
English full-text Citations (21)
DOI: https://doi.org/10.1070/RCR4841
Abstract: The review summarizes recent advances in the synthesis of new derivatives of polyene macrolide antibiotics by chemical modification and genetic engineering methods, results of structure–activity relationship studies and progress in the development of effective and safe drug formulations of this class of antibiotics. Attention is focused on structural changes of polyenes, resulting in a significant decrease in toxicity with retention or even enhancement of antifungal activity. Current concepts on the mechanisms of biological action of these antiobiotics in terms of their therapeutic activity and toxicity are considered.
The bibliography includes 77 references.
Received: 06.06.2018
Russian version:
Uspekhi Khimii, 2018, Volume 87, Issue 12, Pages 1206–1225
DOI: https://doi.org/10.1070/RCR4841
Bibliographic databases:
Document Type: Article
Language: English
Original paper language: Russian
Citation: O. A. Omelchuk, A. N. Tevyashova, A. E. Shchekotikhin, “Recent advances in antifungal drug discovery based on polyene macrolide antibiotics”, Usp. Khim., 87:12 (2018), 1206–1225; Russian Chem. Reviews, 87:12 (2018), 1206–1225
Citation in format AMSBIB
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\by O.~A.~Omelchuk, A.~N.~Tevyashova, A.~E.~Shchekotikhin
\paper Recent advances in antifungal drug discovery based on polyene macrolide antibiotics
\jour Usp. Khim.
\yr 2018
\vol 87
\issue 12
\pages 1206--1225
\mathnet{http://mi.mathnet.ru/rcr4236}
\crossref{https://doi.org/10.1070/RCR4841}
\adsnasa{https://adsabs.harvard.edu/cgi-bin/bib_query?2018RuCRv..87.1206O}
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\transl
\jour Russian Chem. Reviews
\yr 2018
\vol 87
\issue 12
\pages 1206--1225
\crossref{https://doi.org/10.1070/RCR4841}
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\scopus{https://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85058142864}
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  • https://doi.org/10.1070/RCR4841
  • https://www.mathnet.ru/eng/rcr/v87/i12/p1206
    • This publication is cited in the following 21 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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