Abstract:
The review summarizes recent advances in the synthesis of new derivatives of polyene macrolide antibiotics by chemical modification and genetic engineering methods, results of structure–activity relationship studies and progress in the development of effective and safe drug formulations of this class of antibiotics. Attention is focused on structural changes of polyenes, resulting in a significant decrease in toxicity with retention or even enhancement of antifungal activity. Current concepts on the mechanisms of biological action of these antiobiotics in terms of their therapeutic activity and toxicity are considered.
The bibliography includes 77 references.
Received: 06.06.2018
Bibliographic databases:
Document Type:
Article
Language: English
Original paper language: Russian
Citation:
O. A. Omelchuk, A. N. Tevyashova, A. E. Shchekotikhin, “Recent advances in antifungal drug discovery based on polyene macrolide antibiotics”, Russian Chem. Reviews, 87:12 (2018), 1206–1225
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\paper Recent advances in antifungal drug discovery based on polyene macrolide antibiotics
\jour Russian Chem. Reviews
\yr 2018
\vol 87
\issue 12
\pages 1206--1225
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Linking options:
https://www.mathnet.ru/eng/rcr4236
https://doi.org/10.1070/RCR4841
https://www.mathnet.ru/eng/rcr/v87/i12/p1206
This publication is cited in the following 24 articles:
Elena V. Kulyabina, Andrey E. Shchekotikhin, Anna N. Tevyashova, Tatiana V. Kulyabina, Valeria V. Morozova, Reference Materials in Measurement and Technology, 2024, 31
Lingdai Liu, Simon Swift, John Taylor, Ashley N. Nutsford, Cherie Tollemache, Ziqi Lu, Pooja Yadav, Zoran Zujovic, Jacqueline Ross, Joseph Vella, Shurui Chen, Janesha Perera, Dan Li, Paul A. Kilmartin, Chemical Engineering Journal, 481 (2024), 148406
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E. N. Olsufyeva, A. E. Shchekotikhin, Russ Chem Bull, 73:12 (2024), 3523
E. E. Musayev, T. B. Chistyakova, V. A. Kolodyaznaya, V. V. Belakhov, Cyber-Physical Systems and Control II, Lecture Notes in Networks and Systems, 460, 2023, 260
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E. V. Kulyabina, A. E. Shchekotikhin, A. N. Tevyashova, T. V. Kulyabina, V. V. Morozova, Stand. obraz., 19:4 (2023), 17
A. Mahor, D. M. Sawant, A. K. Goyal, Current Computer-Aided Drug Design, 19:5 (2023), 382
V. V. Belakhov, Russ. J .Gen. Chem., 92:13 (2022), 3030
A. Mahor, D. M. Sawant, A. K. Goyal, Current Topics in Medicinal Chemistry, 22:19 (2022), 1571
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V. V. Belakhov, Russ. J. Gen. Chem., 91:13 (2021), 2858–2880
Ortega-Blake I., Fernandez-Zertuche M., Regla I., Sanchez-Pena W., Gomez-Solis A., Jaimes-Chavez P., Galvan-Hernandez A., Tovar-Garduno E., Rodriguez-Fragoso L., Basic Clin. Pharmacol. Toxicol., 129:1 (2021), 72–81
Jiang L., Huang P., Ren B., Song Zh., Zhu G., He W., Zhang J., Oyeleye A., Dai H., Zhang L., Liu X., Appl. Microbiol. Biotechnol., 105:12 (2021), 4975–4986
V. V. Belakhov, T. B. Chistyakova, E. E. Musayev, I. A. Smirnov, V. A. Kolodyaznaya, Russ. J. Gen. Chem., 91:6 (2021), 1028–1038
A. N. Tevyashova, E. N. Bychkova, S. E. Solovieva, G. V. Zatonsky, N. E. Grammatikova, E. B. Isakova, E. P. Mirchink, I. D. Treshchalin, E. R. Pereverzeva, E. E. Bykov, S. S. Efimova, O. S. Ostroumova, A. E. Shchekotikhin, ACS Infect. Dis., 6:8 (2020), 2029–2044
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