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This article is cited in 5 scientific papers (total in 5 papers)
Development of concepts on the interaction of drugs with opioid receptors
N. E. Kuzminaa, V. S. Kuzminb a State Scientific-Research Institute of Organic Chemistry and Technology
b I. M. Sechenov First Moscow State Medical University
Abstract:
The development of concepts on the molecular mechanisms of the action of medicinal drugs on the opioid receptors is briefly surveyed. The modern point of view on the mechanism of activation of opioid receptors is given based on the data from chimeric and site-directed mutagenesis of the cloned opioid receptors and the computer-aided simulations of the reception zone and ligand–receptor complexes. Three-dimensional models of the opioid pharmacophore derived by both conventional methods and a comparative analysis of molecular fields are described in detail.
Received: 05.07.2010
Citation:
N. E. Kuzmina, V. S. Kuzmin, “Development of concepts on the interaction of drugs with opioid receptors”, Usp. Khim., 80:2 (2011), 157–181; Russian Chem. Reviews, 80:2 (2011), 145–169
Linking options:
https://www.mathnet.ru/eng/rcr42https://doi.org/10.1070/RC2011v080n02ABEH004171 https://www.mathnet.ru/eng/rcr/v80/i2/p157
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