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Russian Chemical Reviews, 2017, Volume 86, Issue 3, Pages 231–239
DOI: https://doi.org/10.1070/RCR4636 (Mi rcr4155) 		 
This article is cited in 77 scientific papers (total in 77 papers)

Chitosan and its derivatives: vectors in gene therapy

A. S. Kritchenkovab, S. Andranovitšc, Yu. A. Skorikad

a Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg
b St. Petersburg State University, Institute of Chemistry
c University of Vienna, Austria
d Institute of Experimental Medicine, Federal V. A. Almazov North-West Medical Research Centre, Saint Petersburg
English full-text Citations (77)
DOI: https://doi.org/10.1070/RCR4636
Abstract: The review deals with the use of chitosan and its derivatives as vectors for delivery of nucleic acids in gene therapy. Factors influencing the transfection efficiency of chitosan-based polyplexes (molecular weight, the degree of deacetylation, pH, type of chemical modification, type of transfected cells) are discussed. Particular attention is paid to methods of chemical modification of chitosan (covalent hydrophilic and hydrophobic modification and non-covalent modification), which are able to increase the transfection efficiency and to provide targeted delivery of nucleic acids.
The bibliography includes 151 references.
Funding agency Grant number
Russian Foundation for Basic Research 16-34-60173
Saint Petersburg State University 2.38.220.2015
Received: 17.02.2016
Russian version:
Uspekhi Khimii, 2017, Volume 86, Issue 3, Pages 231–239
DOI: https://doi.org/10.1070/RCR4636
Bibliographic databases:
Document Type: Article
Language: English
Original paper language: Russian
Citation: A. S. Kritchenkov, S. Andranovitš, Yu. A. Skorik, “Chitosan and its derivatives: vectors in gene therapy”, Usp. Khim., 86:3 (2017), 231–239; Russian Chem. Reviews, 86:3 (2017), 231–239
Citation in format AMSBIB
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\paper Chitosan and its derivatives: vectors in gene therapy
\jour Usp. Khim.
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\issue 3
\pages 231--239
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\pages 231--239
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    • This publication is cited in the following 77 articles:
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