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Russian Chemical Reviews, 2016, Volume 85, Issue 7, Pages 759–793
DOI: https://doi.org/10.1070/RCR4591 (Mi rcr4119) 		 
This article is cited in 16 scientific papers (total in 16 papers)

Synthesis and antitumour activity of 4-aminoquinazoline derivatives

G. N. Lipunovaa, E. V. Nosovaab, V. N. Charushinab, O. N. Chupakhinab

a I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, Ekaterinburg
b Ural Federal University named after the First President of Russia B. N. Yeltsin, Ekaterinburg
English full-text Citations (16)
DOI: https://doi.org/10.1070/RCR4591
Abstract: Pieces of data on the synthesis and antitumour activity of 4-aminoquinazolines are summarized and analyzed. Key methods for the synthesis of these compounds are considered, primarily cyclocondensation of carboxylic acid derivatives, as well as the oxidation of quinazolines and the cyclization of disubstituted thioureas. Improvements of synthetic schemes for erlotinib, gefitinib and lapatinib, which are the best-known pharmaceuticals based on compounds of the title class, are also considered. Synthetic strategies and biological activities for new 4-aminoquinazoline derivatives that are EGFR-tyrosine kinase inhibitors, multiactive compounds, and labelled compounds for use as positron emission tomography (PET) imaging agents are discussed.
The bibliography includes 263 references.
Received: 28.07.2015
Russian version:
Uspekhi Khimii, 2016, Volume 85, Issue 7, Pages 759–793
DOI: https://doi.org/10.1070/RCR4591
Bibliographic databases:
Document Type: Article
Language: English
Original paper language: Russian
Citation: G. N. Lipunova, E. V. Nosova, V. N. Charushin, O. N. Chupakhin, “Synthesis and antitumour activity of 4-aminoquinazoline derivatives”, Usp. Khim., 85:7 (2016), 759–793; Russian Chem. Reviews, 85:7 (2016), 759–793
Citation in format AMSBIB
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\by G.~N.~Lipunova, E.~V.~Nosova, V.~N.~Charushin, O.~N.~Chupakhin
\paper Synthesis and antitumour activity of 4-aminoquinazoline derivatives
\jour Usp. Khim.
\yr 2016
\vol 85
\issue 7
\pages 759--793
\mathnet{http://mi.mathnet.ru/rcr4119}
\crossref{https://doi.org/10.1070/RCR4591}
\adsnasa{https://adsabs.harvard.edu/cgi-bin/bib_query?2016RuCRv..85..759L}
\elib{https://elibrary.ru/item.asp?id=26337826}
\transl
\jour Russian Chem. Reviews
\yr 2016
\vol 85
\issue 7
\pages 759--793
\crossref{https://doi.org/10.1070/RCR4591}
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\scopus{https://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84981510538}
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  • https://www.mathnet.ru/eng/rcr4119
  • https://doi.org/10.1070/RCR4591
  • https://www.mathnet.ru/eng/rcr/v85/i7/p759
    • This publication is cited in the following 16 articles:
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