Abstract:
Being structural analogues of natural microtubule-destabilizing cytostatics, polyalkoxyflavonoids represent a promising class of compounds for anticancer drug design. The review covers synthetic routes to various polyalkoxyflavonoids and the results of biological assays in vitro on human cancer cells and \it{in vivo} using sea urchin embryos as a model. Mechanisms of action and structure–relationship activity for polyalkoxyflavonoids are discussed. The bibliography includes 151 references.
Received: 24.02.2014
Bibliographic databases:
Language: English
Original paper language: Russian
Citation:
V. V. Semenov, M. N. Semenova, “Polyalkoxyflavonoids as inhibitors of cell division”, Russian Chem. Reviews, 84:2 (2015), 134–158
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