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This article is cited in 15 scientific papers (total in 15 papers)
Polyalkoxyflavonoids as inhibitors of cell division
V. V. Semenova, M. N. Semenovab a N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
b Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
Abstract:
Being structural analogues of natural microtubule-destabilizing cytostatics, polyalkoxyflavonoids represent a promising class of compounds for anticancer drug design. The review covers synthetic routes to various polyalkoxyflavonoids and the results of biological assays in vitro on human cancer cells and \it{in vivo} using sea urchin embryos as a model. Mechanisms of action and structure–relationship activity for polyalkoxyflavonoids are discussed. The bibliography includes 151 references.
Received: 24.02.2014
Citation:
V. V. Semenov, M. N. Semenova, “Polyalkoxyflavonoids as inhibitors of cell division”, Usp. Khim., 84:2 (2015), 134–158; Russian Chem. Reviews, 84:2 (2015), 134–158
Linking options:
https://www.mathnet.ru/eng/rcr4032https://doi.org/10.1070/RCR4449 https://www.mathnet.ru/eng/rcr/v84/i2/p134
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