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Russian Chemical Reviews, 2015, Volume 84, Issue 1, Pages 1–26
DOI: https://doi.org/10.1070/RCR4459 (Mi rcr4026) 		 
This article is cited in 68 scientific papers (total in 68 papers)

Man-made antibodies and immunoconjugates with desired properties: function optimization using structural engineering

S. M. Deyev, E. N. Lebedenko, L. E. Petrovskaya, D. A. Dolgikh, A. G. Gabibov, M. P. Kirpichnikov

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow
English full-text Citations (68)
DOI: https://doi.org/10.1070/RCR4459
Abstract: The review outlines progress and problems in the design of non-natural antibodies for clinical applications over the past 10–15 years. The modular structure of natural antibodies and approaches to its targeted modifications and combination with other structural elements and effector molecules are considered. The review covers modern methods for immunoglobulin engineering and promising strategies for the creation and applications of monoclonal antibodies, their derivatives and analogues, including abzymes and scaffolds, oriented to the use in the diagnosis and targeted therapy of cancer and other socially significant diseases.
The bibliography includes 225 references.
Received: 04.04.2014
Russian version:
Uspekhi Khimii, 2015, Volume 84, Issue 1, Pages 1–26
DOI: https://doi.org/10.1070/RCR4459
Bibliographic databases:
Document Type: Article
Language: English
Original paper language: Russian
Citation: S. M. Deyev, E. N. Lebedenko, L. E. Petrovskaya, D. A. Dolgikh, A. G. Gabibov, M. P. Kirpichnikov, “Man-made antibodies and immunoconjugates with desired properties: function optimization using structural engineering”, Usp. Khim., 84:1 (2015), 1–26; Russian Chem. Reviews, 84:1 (2015), 1–26
Citation in format AMSBIB
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  • https://doi.org/10.1070/RCR4459
  • https://www.mathnet.ru/eng/rcr/v84/i1/p1
    • This publication is cited in the following 68 articles:
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