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This article is cited in 34 scientific papers (total in 34 papers)
Chemical modification of antifungal polyene macrolide antibiotics
S. E. Solovieva, E. N. Olsufyeva, M. N. Preobrazhenskaya G. F. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow
Abstract:
The review summarizes advances in the methods for the synthesis of polyene antibiotics (amphotericin B, partricin A, etc.) and investigations of the structure–activity relationship made in the last 15 years. State-of-the-art approaches based on the combination of the chemical synthesis and genetic engineering are considered. Emphasis is given to the design of semisynthetic antifungal agents against chemotherapy-resistant pathogens having the highest therapeutic indices. Recent results of research on the mechanisms of action of polyenes are outlined.
Received: 19.02.2010
Citation:
S. E. Solovieva, E. N. Olsufyeva, M. N. Preobrazhenskaya, “Chemical modification of antifungal polyene macrolide antibiotics”, Usp. Khim., 80:2 (2011), 115–138; Russian Chem. Reviews, 80:2 (2011), 103–126
Linking options:
https://www.mathnet.ru/eng/rcr40https://doi.org/10.1070/RC2011v080n02ABEH004145 https://www.mathnet.ru/eng/rcr/v80/i2/p115
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