|
This article is cited in 11 scientific papers (total in 11 papers)
Carboxylic Acid Esters as Substrates of Cholinesterases
A. P. Brestkina, E. V. Rozengarta, A. A. Abduvakhabovb, A. S. Sadykovb a I. M. Sechenov Leningrad Institute of Evolutionary Physiology and Biochemistry, Leningrad
b Institute of Bioorganic Chemistry UzSSR, Tashkent
Abstract:
Data on the kinetics of the hydrolysis of various carboxylic acid esters by two main types of cholinesterases – acetylcholinesterase from human erythrocytes and butyrylcholinesterase from horse blood serum – are surveyed. It is shown that the rate of enzyme hydrolysis depends significantly on the structure of the acyl part of the ester molecule, the nature of the ester heteroatom, the structure of the alcohol component, and particularly the structure of the onium group. Esters based on natural products are of special interest as specific substrates of these enzymes. The role of the productive and non-productive sorption of the substrates in enzyme catalysis is demonstrated. The bibliography includes 81 references.
Citation:
A. P. Brestkin, E. V. Rozengart, A. A. Abduvakhabov, A. S. Sadykov, “Carboxylic Acid Esters as Substrates of Cholinesterases”, Usp. Khim., 52:10 (1983), 1624–1647; Russian Chem. Reviews, 52:10 (1983), 931–943
Linking options:
https://www.mathnet.ru/eng/rcr3500https://doi.org/10.1070/RC1983v052n10ABEH002897 https://www.mathnet.ru/eng/rcr/v52/i10/p1624
|
Statistics & downloads: |
Abstract page: | 82 |
|