Optical Isomers in Solution Investigated by Nuclear Magnetic Resonance

Work during recent years on the n.m.r. spectroscopy of solutions of optical antipodes and their mixtures with each other and with epimers is surveyed. The phenomenon of statistically controlled anisochronism of diastereomeric association (SCADA) is described. Several factors – the nature of the stereoisomers, the solvent, the temperature, etc. – affect the multiplicity of the diastereomeric anisochronism spectra. The above phenomenon is not observed in the absence of association. A theory of the phenomenon is given, and theoretical calculations are compared with experimental results.
A list of 41 references is included.