Preparation of N-Substituted Thiourea

Results on the preparation of N-substituted thioureas by the reaction of organic isothiocyanates with compounds containing an amino-grqup, by the action of alkali-metal thiocyanates on amine hydrochlorides, and by the treatment of primary and secondary amines with thiocarbonyl chloride or carbon disulphide, published in the Soviet and foreign literature including 1972, are systematically discussed. The reactions of hydrogen sulphide with substituted cyanamides and of thiourea with compounds containing various functional groups are also examined. Certain views are presented on the mechanism of the formation of N-substituted thioureas, and the advantages and disadvantages of various methods for their preparation are compared. Practical applications of N-substituted thioureas are considered. A list of 247 references is included.