M. I. Kabachnik, A. A. Abduvakhabov, I. I. Agabekova, A. P. Brestkin, R. I. Volkova, N. N. Godovikov, E. I. Godyna, S. S. Mikhailov, M. Ya. Mikhel'son, V. I. Rosengart, E. V. Rozengart, R. V. Sitkevich, “Hydrophobic Regions on the Active Surface of Choline-esterases”, Usp. Khim., 39:6 (1970), 1050–1073; Russian Chem. Reviews, 39:6 (1970), 485

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Russian Chemical Reviews, 1970, Volume 39, Issue 6, Pages 485–497
DOI: https://doi.org/10.1070/RC1970v039n06ABEH002001 (Mi rcr2365)

This article is cited in 16 scientific papers (total in 16 papers)

Hydrophobic Regions on the Active Surface of Choline-esterases

M. I. Kabachnik^abc, A. A. Abduvakhabov^abc, I. I. Agabekova^abc, A. P. Brestkin^abc, R. I. Volkova^abc, N. N. Godovikov^abc, E. I. Godyna^abc, S. S. Mikhailov^abc, M. Ya. Mikhel'son^abc, V. I. Rosengart^abc, E. V. Rozengart^abc, R. V. Sitkevich^abc

^a I. M. Sechenov Leningrad Institute of Evolutionary Physiology and Biochemistry
^b A. N. Nesmeyanov Institute of Organoelement Compounds, USSR Academy of Sciences, Moscow
^c 1st Leningrad Medical Institute

English full-text Citations (16)

DOI: https://doi.org/10.1070/RC1970v039n06ABEH002001

Abstract: The methods of synthesis of S-alkyl(aryl) derivatives of methylphosphonothioic acid and methods for the investigation of their anticholine-esterase activity have been briefly described. Data confirming the anticholine-esterase activity of the compounds synthesised are presented.
It has been shown that, in the inhibition of choline-esterases by organophosphorus compounds, the hydrophobic sorption of these substances on the active surface of the enzymes plays an important and sometimes a decisive role.
It is suggested that the presence of hydrophobic regions on the active surface of choline-esterases tends to increase the probability of the sorption of acetylcholine (a choline esterase substrate) on this surface.
The bibliography includes 68 references.

Russian version:
Uspekhi Khimii, 1970, Volume 39, Issue 6, Pages 1050–1073
DOI: https://doi.org/10.1070/RC1970v039n06ABEH002001

Bibliographic databases:

Document Type: Article

UDC: 577.15:577.153.4

Language: English

Original paper language: Russian

Citation: M. I. Kabachnik, A. A. Abduvakhabov, I. I. Agabekova, A. P. Brestkin, R. I. Volkova, N. N. Godovikov, E. I. Godyna, S. S. Mikhailov, M. Ya. Mikhel'son, V. I. Rosengart, E. V. Rozengart, R. V. Sitkevich, “Hydrophobic Regions on the Active Surface of Choline-esterases”, Usp. Khim., 39:6 (1970), 1050–1073; Russian Chem. Reviews, 39:6 (1970), 485–497

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This publication is cited in the following 16 articles:

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