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Russian Chemical Reviews, 1970, Volume 39, Issue 6, Pages 485–497
DOI: https://doi.org/10.1070/RC1970v039n06ABEH002001
(Mi rcr2365)
 

This article is cited in 16 scientific papers (total in 16 papers)

Hydrophobic Regions on the Active Surface of Choline-esterases

M. I. Kabachnikabc, A. A. Abduvakhabovabc, I. I. Agabekovaabc, A. P. Brestkinabc, R. I. Volkovaabc, N. N. Godovikovabc, E. I. Godynaabc, S. S. Mikhailovabc, M. Ya. Mikhel'sonabc, V. I. Rosengartabc, E. V. Rozengartabc, R. V. Sitkevichabc

a I. M. Sechenov Leningrad Institute of Evolutionary Physiology and Biochemistry
b A. N. Nesmeyanov Institute of Organoelement Compounds, USSR Academy of Sciences, Moscow
c 1st Leningrad Medical Institute
Abstract: The methods of synthesis of S-alkyl(aryl) derivatives of methylphosphonothioic acid and methods for the investigation of their anticholine-esterase activity have been briefly described. Data confirming the anticholine-esterase activity of the compounds synthesised are presented.
It has been shown that, in the inhibition of choline-esterases by organophosphorus compounds, the hydrophobic sorption of these substances on the active surface of the enzymes plays an important and sometimes a decisive role.
It is suggested that the presence of hydrophobic regions on the active surface of choline-esterases tends to increase the probability of the sorption of acetylcholine (a choline esterase substrate) on this surface.
The bibliography includes 68 references.
Bibliographic databases:
Document Type: Article
UDC: 577.15:577.153.4
Language: English
Original paper language: Russian


Citation: M. I. Kabachnik, A. A. Abduvakhabov, I. I. Agabekova, A. P. Brestkin, R. I. Volkova, N. N. Godovikov, E. I. Godyna, S. S. Mikhailov, M. Ya. Mikhel'son, V. I. Rosengart, E. V. Rozengart, R. V. Sitkevich, “Hydrophobic Regions on the Active Surface of Choline-esterases”, Usp. Khim., 39:6 (1970), 1050–1073; Russian Chem. Reviews, 39:6 (1970), 485–497
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  • https://doi.org/10.1070/RC1970v039n06ABEH002001
  • https://www.mathnet.ru/eng/rcr/v39/i6/p1050
  • This publication is cited in the following 16 articles:
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