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This article is cited in 24 scientific papers (total in 24 papers)
Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs
I. V. Serkova, V. V. Bezuglovb a Institute of Physiologically Active Compounds RAS, Chernogolovka
b M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
of the Russian Academy of Sciences, Moscow
Abstract:
The modern trend in medicinal chemistry consists of designing multifunctional drugs with a wide variety of targets. This review considers one of the ways of development of such drugs, namely, the introduction of nitrogen monoxide-generating fragments into molecules of known drugs. Examples of syntheses and the results of biological activity assays are shown for O-nitro derivatives of various drugs.
Received: 16.01.2009
Citation:
I. V. Serkov, V. V. Bezuglov, “Multifunctional compounds containing organic nitrates as prototypes of hybrid drugs”, Usp. Khim., 78:5 (2009), 442–465; Russian Chem. Reviews, 78:5 (2009), 407–429
Linking options:
https://www.mathnet.ru/eng/rcr166https://doi.org/10.1070/RC2009v078n05ABEH004024 https://www.mathnet.ru/eng/rcr/v78/i5/p442
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