|
This article is cited in 23 scientific papers (total in 23 papers)
Radical chemistry of artemisinin
E. T. Denisov, S. L. Solodova, T. G. Denisova Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region
Abstract:
The review summarizes physicochemical characteristics of the natural sesquiterpene peroxide artemisinin. The kinetic schemes of transformations of artemisinin radicals under anaerobic conditions are presented and analyzed. The sequence of radical reactions of artemisinin in the presence of oxygen is considered in detail. Special emphasis is given to the intramolecular chain oxidation resulting in the transformation of artemisinin into polyatomic hydroperoxide. The kinetic characteristics of elementary reaction steps involving alkyl, alkoxyl, and peroxyl radicals generated from artemisinin are discussed. The results of testing of artemisinin and its derivatives for the antimalarial activity and the scheme of the biochemical synthesis of artemisinin in nature are considered.
Received: 03.02.2010
Citation:
E. T. Denisov, S. L. Solodova, T. G. Denisova, “Radical chemistry of artemisinin”, Usp. Khim., 79:11 (2010), 1065–1088; Russian Chem. Reviews, 79:11 (2010), 981–1003
Linking options:
https://www.mathnet.ru/eng/rcr140https://doi.org/10.1070/RC2010v079n11ABEH004143 https://www.mathnet.ru/eng/rcr/v79/i11/p1065
|
Statistics & downloads: |
Abstract page: | 217 |
|