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Russian Chemical Reviews, 1992, Volume 61, Issue 10, Pages 999–1008
DOI: https://doi.org/10.1070/RC1992v061n10ABEH001012
(Mi rcr1060)
 

This article is cited in 2 scientific papers (total in 2 papers)

Kinetic isotope effects in the enzymic reactions of tritium- and deuterium-containing substrates

G. P. Akulov

RPA 'V. G. Khlopin Radium Institute', St. Petersburg
English full-text Citations (2)
Abstract: The kinetic differences between the enzymic reactions involving substrates containing heavy hydrogen isotopes are examined. Theoretical estimates and numerous examples of experimentally measured kinetic isotope effects in various enzymic reaction are presented. The kinetic isotope effects are widely used in studies of the mechanisms of enzymic reactions and of the structures of the enzyme–substrate complexes, for the enrichment of labelled compounds in heavy hydrogen isotopes, and also in certain fields of medicine and biochemistry.
The bibliography includes 99 references.
Received: 16.03.1992
Russian version:
Uspekhi Khimii, 1992, Volume 61, Issue 10, Pages 1822–1838
DOI: https://doi.org/10.1070/RC1992v061n10ABEH001012
Bibliographic databases:
Document Type: Article
UDC: 541.127:577.151
Language: English
Original paper language: Russian


Citation: G. P. Akulov, “Kinetic isotope effects in the enzymic reactions of tritium- and deuterium-containing substrates”, Usp. Khim., 61:10 (1992), 1822–1838; Russian Chem. Reviews, 61:10 (1992), 999–1008
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  • https://www.mathnet.ru/eng/rcr/v61/i10/p1822
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