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This article is cited in 9 scientific papers (total in 9 papers)
Small-molecule caspase inhibitors
S. M. Zhenodarova Institute for Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region
Abstract:
The review considers low-molecular weight inhibitors of caspases, cysteine proteases being key contributors to apoptosis (programmed cell death). The inhibitors with aspartic acid residues or various heterocyclic systems (both synthetic and natural) are covered. Their possible mechanisms of action are discussed. Data on inhibitor structure-activity relationship studies are systematically surveyed. The interactions of the non-peptide fragments of an inhibitor with the enzymes are examined. Examples of the use of some inhibitors for apoptosis suppression are provided.
Received: 01.04.2009
Citation:
S. M. Zhenodarova, “Small-molecule caspase inhibitors”, Usp. Khim., 79:2 (2010), 135–161; Russian Chem. Reviews, 79:2 (2010), 119–143
Linking options:
https://www.mathnet.ru/eng/rcr100https://doi.org/10.1070/RC2010v079n02ABEH004056 https://www.mathnet.ru/eng/rcr/v79/i2/p135
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