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Kvantovaya Elektronika, 2021, Volume 51, Number 2, Pages 118–123 (Mi qe17402)  

This article is cited in 4 scientific papers (total in 4 papers)

Laser biophotonics

Polyacrylamide-based phantoms of human skin for hyperspectral fluorescence imaging and spectroscopy

V. V. Shupletsova, E. A. Zherebtsovab, V. V. Dreminac, A. P. Popovd, A. V. Bykovb, E. V. Potapovaa, A. V. Dunaeva, I. V. Meglinskibcef

a Research and Development Centre of Biomedical Photonics, Orel State University
b Optoelectronics and Measurements Techniques Unit, University of Oulu, Finland
c College of Engineering and Physical Sciences, Aston University, UK
d VTT Technical Research Centre of Finland, Oulu, Finland
e National Engineering Physics Institute "MEPhI", Moscow
f I. M. Sechenov First Moscow State Medical University
References:
Abstract: Based on the combined use of polymerisable polyacrylamide, collagen and an aqueous solution of Flavin adenine dinucleotide (FAD), we have developed a new technique for fabrication of composite phantoms mimicking fluorescence properties of human skin. A comparative analysis of the absorption and scattering coefficients, refractive indices, as well as fluorescence spectra of phantoms with different concentrations of FAD measured with the combined use of a CCD spectrometer and a hyperspectral camera is presented. To obtain values of scattering coefficients close to those for human skin, zinc oxide (ZnO) nanoparticles are added to the polyacrylamide polymer structure. Variations both in the shape of the spectrum and in the intensity of the fluorescence signal in the phantoms are provided by the changes in the volume fraction of FAD and collagen. It is shown that the model fluorescence spectra are in good agreement with the results of direct human skin measurements in vivo.
Keywords: optical properties, human skin, phantoms, collagen, flavin adenine dinucleotide, hyperspectral imaging, fluorescence spectroscopy.
Funding agency Grant number
Russian Foundation for Basic Research 18-02-00669
Russian Science Foundation 19-72-30012
20-75-00123
Academy of Finland 326204
325097
EU Framework Programme for Research and Innovation 839888
Received: 21.12.2020
English version:
Quantum Electronics, 2021, Volume 51, Issue 2, Pages 118–123
DOI: https://doi.org/10.1070/QEL17513
Bibliographic databases:
Document Type: Article
Language: Russian


Citation: V. V. Shupletsov, E. A. Zherebtsov, V. V. Dremin, A. P. Popov, A. V. Bykov, E. V. Potapova, A. V. Dunaev, I. V. Meglinski, “Polyacrylamide-based phantoms of human skin for hyperspectral fluorescence imaging and spectroscopy”, Kvantovaya Elektronika, 51:2 (2021), 118–123 [Quantum Electron., 51:2 (2021), 118–123]
Linking options:
  • https://www.mathnet.ru/eng/qe17402
  • https://www.mathnet.ru/eng/qe/v51/i2/p118
  • This publication is cited in the following 4 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
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