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This article is cited in 6 scientific papers (total in 6 papers)
Extreme laser radiation: physics and fundamental applications
Experimental stand for studying the impact of laser-accelerated protons on biological objects
K. F. Burdonova, A. A. Eremeeva, N. I. Ignatovab, R. R. Osmanova, A. D. Sladkova, A. A. Solovieva, M. V. Starodubtseva, V. N. Ginzburga, A. A. Kuzmina, A. V. Maslennikovab, G. Revetca, A. M. Sergeeva, J. Fuchsca, E. A. Khazanova, S. Chenca, A. A. Shaikina, I. A. Shaikina, I. V. Yakovleva a Institute of Applied Physics of the Russian Academy of Sciences, Nizhnii Novgorod
b Nizhny Novgorod Medical Academy
c École Polytechnique, France
Abstract:
An original experimental stand is presented, aimed at studying the impact of high-energy protons, produced by the laser-plasma interaction at a petawatt power level, on biological objects. In the course of pilot experiments with the energy of laser-accelerated protons up to 25 MeV, the possibility is demonstrated of transferring doses up to 10 Gy to the object of study in a single shot with the magnetic separation of protons from parasitic X-ray radiation and fast electrons. The technique of irradiating the cell culture HeLa Kyoto and measuring the fraction of survived cells is developed. The ways of optimising the parameters of proton beams and the suitable methods of their separation with respect to energy and transporting to the studied living objects are discussed. The construction of the stand is intended for the improvement of laser technologies for hadron therapy of malignant neoplasms.
Keywords:
laser-plasma interaction, high-energy protons, irradiation of cell cultures.
Received: 24.02.2016
Citation:
K. F. Burdonov, A. A. Eremeev, N. I. Ignatova, R. R. Osmanov, A. D. Sladkov, A. A. Soloviev, M. V. Starodubtsev, V. N. Ginzburg, A. A. Kuzmin, A. V. Maslennikova, G. Revet, A. M. Sergeev, J. Fuchs, E. A. Khazanov, S. Chen, A. A. Shaikin, I. A. Shaikin, I. V. Yakovlev, “Experimental stand for studying the impact of laser-accelerated protons on biological objects”, Kvantovaya Elektronika, 46:4 (2016), 283–287 [Quantum Electron., 46:4 (2016), 283–287]
Linking options:
https://www.mathnet.ru/eng/qe16366 https://www.mathnet.ru/eng/qe/v46/i4/p283
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