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Kvantovaya Elektronika, 2015, Volume 45, Number 4, Pages 358–365 (Mi qe16144)  

This article is cited in 6 scientific papers (total in 6 papers)

Biophotonics

Method for estimating optimal spectral and energy parameters of laser irradiation in photodynamic therapy of biological tissue

S. A. Lisenko, M. M. Kugeiko

Belarusian State University, Minsk
Full-text PDF (758 kB) Citations (6)
References:
Abstract: We have solved the problem of layer-by-layer laser-light dosimetry in biological tissues and of selecting an individual therapeutic dose in laser therapy. A method is proposed for real-time monitoring of the radiation density in tissue layers in vivo, concentrations of its endogenous (natural) and exogenous (specially administered) chromophores, as well as in-depth distributions of the spectrum of light action on these chromophores. As the background information use is made of the spectrum of diffuse light reflected from a patient's tissue, measured by a fibre-optic spectrophotometer. The measured spectrum is quantitatively analysed by the method of approximating functions for fluxes of light multiply scattered in tissue and by a semi-analytical method for calculating the in-depth distribution of the light flux in a multi-layered medium. We have shown the possibility of employing the developed method for monitoring photosensitizer and oxyhaemoglobin concentrations in tissue, light power absorbed by chromophores in tissue layers at different depths and laser-induced changes in the tissue morphology (vascular volume content and ratios of various forms of haemoglobin) during photodynamic therapy.
Keywords: biological tissue, photodynamic therapy, layer-by-layer dosimetry of laser light, diffuse reflectance, light action spectrum, photodissociation of oxyhaemoglobin.
Received: 13.01.2014
Revised: 02.06.2014
English version:
Quantum Electronics, 2015, Volume 45, Issue 4, Pages 358–365
DOI: https://doi.org/10.1070/QE2015v045n04ABEH015381
Bibliographic databases:
Document Type: Article
PACS: 42.25.Fx, 87.64.Cc, 87.53.Tf
Language: Russian


Citation: S. A. Lisenko, M. M. Kugeiko, “Method for estimating optimal spectral and energy parameters of laser irradiation in photodynamic therapy of biological tissue”, Kvantovaya Elektronika, 45:4 (2015), 358–365 [Quantum Electron., 45:4 (2015), 358–365]
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  • https://www.mathnet.ru/eng/qe16144
  • https://www.mathnet.ru/eng/qe/v45/i4/p358
  • This publication is cited in the following 6 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
    Квантовая электроника Quantum Electronics
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    Abstract page:306
    Full-text PDF :131
    References:46
    First page:12
     
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