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This article is cited in 14 scientific papers (total in 14 papers)
Laser biophotonics
Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography
Woo June Choi, R. K. Wang University of Washington, Department of Bioengineering, Seattle, USA
Abstract:
We demonstrate volumetric cutaneous microangiography of the human skin in vivo that utilises 1.3-μm high-speed sweptsource optical coherence tomography (SS-OCT). The swept source is based on a micro-electro-mechanical (MEMS)-tunable vertical cavity surface emission laser (VCSEL) that is advantageous in terms of long coherence length over 50 mm and 100 nm spectral bandwidth, which enables the visualisation of microstructures within a few mm from the skin surface. We show that the skin microvasculature can be delineated in 3D SS-OCT images using ultrahigh-sensitive optical microangiography (UHS-OMAG) with a correlation mapping mask, providing a contrast enhanced blood perfusion map with capillary flow sensitivity. 3D microangiograms of a healthy human finger are shown with distinct cutaneous vessel architectures from different dermal layers and even within hypodermis. These findings suggest that the OCT microangiography could be a beneficial biomedical assay to assess cutaneous vascular functions in clinic.
Keywords:
cutaneous microcirculation, swept-source optical coherence tomography, vertical cavity surface emission laser, ultrahighsensitive optical microangiography, correlation mapping optical coherence tomography.
Received: 30.03.2014 Revised: 15.06.2014
Citation:
Woo June Choi, R. K. Wang, “Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography”, Kvantovaya Elektronika, 44:8 (2014), 740–745 [Quantum Electron., 44:8 (2014), 740–745]
Linking options:
https://www.mathnet.ru/eng/qe16020 https://www.mathnet.ru/eng/qe/v44/i8/p740
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Abstract page: | 209 | Full-text PDF : | 87 | References: | 28 | First page: | 13 |
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