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This article is cited in 11 scientific papers (total in 11 papers)
Optical technologies in biophysics and medicine
Cortexin diffusion in human eye sclera
È. A. Geninaa, A. N. Bashkatova, V. V. Tuchina, M. G. Ghosnb, K. V. Larinb, T. G. Kamenskikhc a OBP Research-Educational Institute of Optics and Biophotonics, Saratov State University
b Department of Chemical and Biomolecular Engineering, University of Houston, USA
c Saratov State Medical University named after V. I. Razumovsky
Abstract:
Investigation of the diffusion of cytamines, a typical representative of which is cortexin, is important for evaluating the drug dose, necessary to provide sufficient concentration of the preparation in the inner tissues of the eye. In the present paper, the cortexin diffusion rate in the eye sclera is measured using the methods of optical coherence tomography (OCT) and reflectance spectroscopy. The technique for determining the diffusion coefficient is based on the registration of temporal dependence of the eye sclera scattering parameters caused by partial replacement of interstitial fluid with the aqueous cortexin solution, which reduces the level of the OCT signal and decreases the reflectance of the sclera. The values of the cortexin diffusion coefficient obtained using two independent optical methods are in good agreement.
Received: 18.04.2011
Citation:
È. A. Genina, A. N. Bashkatov, V. V. Tuchin, M. G. Ghosn, K. V. Larin, T. G. Kamenskikh, “Cortexin diffusion in human eye sclera”, Kvantovaya Elektronika, 41:5 (2011), 407–413 [Quantum Electron., 41:5 (2011), 407–413]
Linking options:
https://www.mathnet.ru/eng/qe14641 https://www.mathnet.ru/eng/qe/v41/i5/p407
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