Application of laser speckles for identification of tissues with pathological changes

Two new techniques for the analysis of speckle-patterns, formed by laser radiation dispersed on histological sections with malignant and non-malignant growths, are proposed. One of these techniques is based on the calculation of invariant Zernike moments of the spatial distribution of the speckle-field intensity. The second technique is based on the calculation of the fractal dimension of the intensity spatial distribution in the speckle structure. It is shown that both these methods yield the same results, which drastically depend on tissue properties. The possibility of using Zernike moments and fractal dimensions, formed by laser light dispersed on histological sections, in in vitro express-diagnostics of tissues with pathological changes is investigated.