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This article is cited in 15 scientific papers (total in 15 papers)
Special issue devoted to multiple radiation scattering in random media
Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea
K. V. Larin, M. G. Ghosn Department of Biomedical Engineering, University of Houston, USA
Abstract:
The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 μm where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09 ± 0.12) × 10-5 and (1.71 ± 0.51) × 10-5 cm s-1, respectively.
Received: 16.05.2006 Revised: 23.08.2006
Citation:
K. V. Larin, M. G. Ghosn, “Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea”, Kvantovaya Elektronika, 36:12 (2006), 1083–1088 [Quantum Electron., 36:12 (2006), 1083–1088]
Linking options:
https://www.mathnet.ru/eng/qe13225 https://www.mathnet.ru/eng/qe/v36/i12/p1083
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