Results of the antitumor viral vaccine introduction regimens study based on mathematical modeling

The mathematical description is presented of the two stages of tumor cells' death as a result of the body's immune response after antitumor viral vaccine introduction. The mathematical description in the form of a system of nonlinear differential equations is realized as a software set by means of the MatLab-Simulink system. As a result of the computing experiment, the two strategies of the effective application of the antitumor viral vaccine were determined. The first strategy leads to complete elimination of the tumor cells after a single-shot administration of the vaccine. The second strategy allows stabilizing tumor size through the recurrent introduction of the vaccine. The approach proposed to explore the effectiveness of vaccine therapy can be applied to different types of experimental tumors and antitumor vaccines.