Using mathematical modeling to assess the effectiveness of anti-tumor vaccine therapy method

On the basis of the antitumor vaccine therapy mathematical model the algorithm is developed for calculating the dosage and viral vaccine introduction moment, at which the immune system response to the virus and infected tumor cells is the most effective. The method is developed of calculating the experimental tumors maximum allowable size, the excess of which reduces the efficiency of the vaccine therapy. The method is based on the mathematical description of the dynamics of fast-proliferating tumor cells fraction decrease with the increase of the tumor size. The graphs are plotted showing the changes of the immune system stimulation effectiveness depending on the dosage and vaccine introduction moment, and allowing the optimal control of the immune response dynamics during vaccine therapy.