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Seminar by Department of Discrete Mathematic, Steklov Mathematical Institute of RAS
October 7, 2014 16:00, Moscow, Steklov Mathematical Institute of RAS, Room 511 (8 Gubkina)
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Signature of a selective sweep in a large population of varying size
Charline Smadi |
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Abstract:
In the absence of other factors, an individual with an advantageous
version of a gene will generally survive longer and have more
offspring. Given enough generations, this can result in the fixation of this
advantageous version. This is called a selective sweep, as the gene
under selection quickly increases in frequency in a population.
In this talk, I will describe the genetic signature left by a selective
sweep in a population described by a multitype birth-and-death process
with density dependent competition. I will study the limit behaviour
for large $K$, where $K$ scales the population size. I will first focus on two
loci: one under selection and one neutral, and distinguish a soft sweep
occurring after an environmental change, from a hard sweep occurring
after a mutation. I will derive the expression of the neutral
proportion variation as a function of the ecological parameters, recombination
probability $r_K$, and $K$, and show that for a hard sweep, two
recombination regimes appear according to the order of $r_K \log K$.
If I have time, I will also mention the three locus case, when we
consider two neutral loci and describe the neutral genealogies during
hard sweep.
These results can be used to detect recent selective events in current
population genetic data.
Language: English
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