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This article is cited in 3 scientific papers (total in 3 papers)
Characteristics of receptor- and transducer-coupled activation of the intracellular signalling in sensory neuron revealed by atomic force microscopy
M. M. Khalisovab, V. A. Penniyaynena, N. A. Esikovac, A. V. Ankudinovbd, B. V. Krylova a Pavlov Institute of Physiology Russian Academy of Sciences
b St. Petersburg National Research University of Information Technologies, Mechanics and Optics
c Institute for Analytical Instrumentation, Russian Academy of Sciences, St. Petersburg
d Ioffe Institute, St. Petersburg
Abstract:
The mechanical properties of sensory neurons upon activation of intracellular cascade processes by comenic acid binding to a membrane opioid-like receptor (receptor-coupled), as well as a very low (endogenous) concentration of ouabain (transducer-coupled), have been investigated. Using atomic force microscopy, it is established that exposure to ouabain, in contrast to the impact of comenic acid, leads to a hardening of the neuron soma. This suggests that the receptor-coupled signal transmission to the cell genome is carried out through mechanisms that are different from the transducer-coupled signal pathways.
Received: 01.07.2016
Citation:
M. M. Khalisov, V. A. Penniyaynen, N. A. Esikova, A. V. Ankudinov, B. V. Krylov, “Characteristics of receptor- and transducer-coupled activation of the intracellular signalling in sensory neuron revealed by atomic force microscopy”, Pisma v Zhurnal Tekhnicheskoi Fiziki, 43:1 (2017), 89–94; Tech. Phys. Lett., 43:1 (2017), 85–87
Linking options:
https://www.mathnet.ru/eng/pjtf6036 https://www.mathnet.ru/eng/pjtf/v43/i1/p89
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