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Pisma v Zhurnal Tekhnicheskoi Fiziki, 2021, Volume 47, Issue 13, Pages 24–27
DOI: https://doi.org/10.21883/PJTF.2021.13.51117.18606 (Mi pjtf4745) 		 
Evaluation of cell viability in living tissue equivalents exposed to pulsed current with a DC offset

E. A. Shershunovaa, I. E. Rebrova, V. V. Mishchenkob, A. I. Kryukovb, E. A. Vorotelyakc, O. S. Rogovayac

a Institute of Problems of Electrophysics of the Russian Academy of Sciences, St. Petersburg
b Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow
c Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
Full-text PDF (521 kB)
DOI: https://doi.org/10.21883/PJTF.2021.13.51117.18606
Abstract: An electrophysical apparatus for combined electroporation and iontophoresis treatment of biological membranes is described. Estimates of cell viability in living tissue equivalents exposed to pulsed current with a dc offset are provided. The values of the electrophysical pulse characteristics compatible with the viability of cells in the living tissue equivalents have been determined. The obtained data suggest that these electrophysical parameters could be used for transportation of pharmaceutical compounds through an equivalent of the round window membrane of the cochlea. A technique of drug administration across biological barriers can be developed based on pulsed electric field equipment to enable drug delivery into the inner ear.
Keywords: pulse current, biological membranes, cell viability.
Funding agency Grant number
Ministry of Education and Science of the Russian Federation 0057-2019-0005
0088-2021-0016
This study was supported by the Ministry of Science and Higher Education of the Russian Federation as a part of state orders nos. 0057-2019-0005 and 0088-2021-0016.
Received: 29.10.2020
Revised: 09.02.2021
Accepted: 02.04.2021
English version:
Technical Physics Letters, 2021, Volume 47, Issue 9, Pages 681–684
DOI: https://doi.org/10.1134/S1063785021070130
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: E. A. Shershunova, I. E. Rebrov, V. V. Mishchenko, A. I. Kryukov, E. A. Vorotelyak, O. S. Rogovaya, “Evaluation of cell viability in living tissue equivalents exposed to pulsed current with a DC offset”, Pisma v Zhurnal Tekhnicheskoi Fiziki, 47:13 (2021), 24–27; Tech. Phys. Lett., 47:9 (2021), 681–684
Citation in format AMSBIB
\Bibitem{SheRebMis21}
\by E.~A.~Shershunova, I.~E.~Rebrov, V.~V.~Mishchenko, A.~I.~Kryukov, E.~A.~Vorotelyak, O.~S.~Rogovaya
\paper Evaluation of cell viability in living tissue equivalents exposed to pulsed current with a DC offset
\jour Pisma v Zhurnal Tekhnicheskoi Fiziki
\yr 2021
\vol 47
\issue 13
\pages 24--27
\mathnet{http://mi.mathnet.ru/pjtf4745}
\crossref{https://doi.org/10.21883/PJTF.2021.13.51117.18606}
\elib{https://elibrary.ru/item.asp?id=46321846}
\transl
\jour Tech. Phys. Lett.
\yr 2021
\vol 47
\issue 9
\pages 681--684
\crossref{https://doi.org/10.1134/S1063785021070130}
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