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Problemy Fiziki, Matematiki i Tekhniki (Problems of Physics, Mathematics and Technics), 2024, Issue 1(58), Pages 50–56
DOI: https://doi.org/10.54341/20778708_2024_1_58_50
(Mi pfmt949)
 

PHYSICS

Molecular structure and anti-fungicidal properties of coatings based on clotrimazole and polymers formed from the active gas phase

M. A. Yarmolenkoa, Jiang Xiao Homgb, A. A. Rogachevc, A. V. Rogacheva, A. S. Rudenkova, O. A. Yarmolenkod, S. A. Frolova

a Francisk Skorina Gomel State University
b Nanjing University of Science and Technology
c Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus, Minsk
d Gomel State Medical University
References:
Abstract: The features of the molecular structure, chemical composition and antifungicidal properties of the coatings based on clotrimazole, polyurethane (PU), polyvinyl chloride (PVC), formed from the active gas phase formed by electron beam dispersion of compounds in a vacuum, were determined. It was found that the chemical composition of the clotrimazole-based coating almost completely corresponds to the chemical composition of the original drug compound. A slight decrease in chlorine in the coating compared to the original drug compound is explained by the partial destruction of C – Cl bonds under the influence of an electron flow. The high efficiency of regulating the prolonged release of a drug compound by forming composite coatings has been established. It has been shown that the fungicidal activity of composite coatings is largely determined by the properties of the polymer matrix. The coatings based on clotrimazole and graphitized PVC exhibit higher activity.
Keywords: electron beam dispersion, coating, clotrimazole, polyurethane, polyvinyl chloride, molecular structure, properties.
Funding agency Grant number
Belarusian Republican Foundation for Fundamental Research Х22КИТГ-024
Ministry of Science and Technology of PRC 2022YFE0196800
Received: 09.01.2024
Bibliographic databases:
Document Type: Article
UDC: 537.533.7:621.793.18:678
Language: Russian
Citation: M. A. Yarmolenko, Jiang Xiao Homg, A. A. Rogachev, A. V. Rogachev, A. S. Rudenkov, O. A. Yarmolenko, S. A. Frolov, “Molecular structure and anti-fungicidal properties of coatings based on clotrimazole and polymers formed from the active gas phase”, PFMT, 2024, no. 1(58), 50–56
Citation in format AMSBIB
\Bibitem{YarHomRog24}
\by M.~A.~Yarmolenko, Jiang~Xiao~Homg, A.~A.~Rogachev, A.~V.~Rogachev, A.~S.~Rudenkov, O.~A.~Yarmolenko, S.~A.~Frolov
\paper Molecular structure and anti-fungicidal properties of coatings based on clotrimazole and polymers formed from the active gas phase
\jour PFMT
\yr 2024
\issue 1(58)
\pages 50--56
\mathnet{http://mi.mathnet.ru/pfmt949}
\crossref{https://doi.org/10.54341/20778708_2024_1_58_50}
\edn{https://elibrary.ru/SILLPY}
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    Проблемы физики, математики и техники
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    Full-text PDF :25
    References:19
     
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