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Optics and Spectroscopy, 2019, Volume 126, Issue 5, Pages 650–655
DOI: https://doi.org/10.21883/OS.2019.05.47666.15-19 (Mi os722) 		 
This article is cited in 5 scientific papers (total in 5 papers)

The 22nd Annual Conference Saratov Fall Meeting 2018 (SFM'18): VI International Symposium ''Optics and Biophotonics'' and XXII International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics
Biophotonics

New opportunities for colorectal cancer diagnostics using an optical cell detection system based on dielectrophoresis

M. V. Kruchininaab, Ya. I. Prudnikovaa, A. A. Gromova, V. M. Generalovc, K. V. Generalovc, V. N. Kruchinind, E. V. Kruchininab, G. V. Shuvalove, I. N. Yakovinaf, N. A. Bannovaf, O. V. Mining, I. V. Minine

a Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
b Novosibirsk State Medical University, Novosibirsk
c State Research Center of Virology and Biotechnology Vector, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Novosibirsk, Koltsovo, Russia
d Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, Novosibirsk
e Federal State Unitary Enterprise "Siberian Scientific Research Institute of Metrology", Novosibirsk
f Novosibirsk State Technical University
g Tomsk State University
Citations (5)
DOI: https://doi.org/10.21883/OS.2019.05.47666.15-19
Abstract: The possibilities of using electrical and viscoelastic parameters of erythrocytes in patients with colorectal cancer (CRC) of different stages were demonstrated using optical cell detection system based on the dielectrophoresis method. The deformation amplitude, portion of deformed cells, generalized viscosity, rigidity, equilibrium frequency position, and electrical conductivity were the most significant parameters for determining patients with CRC, as well as early and late stages, included in the created model of a riskometer for the disease diagnosis. The created diagnostic “panels” with a high diagnostic accuracy, sensitivity, and specificity allowed to one determine patients with CRC (specificity 0.91, sensitivity 0.96), as well as early and late stages of the disease (specificity 0.64, sensitivity 0.86).
Funding agency Grant number
Ministry of Science and Higher Education of the Russian Federation 0324-2018-0001
This work was performed within the theme “Epidemiological Monitoring of Public Health and Study of Molecular Genetic and Molecular Biological Mechanisms of Development of Common Therapeutic Diseases in Siberia to Improve Approaches to Their Diagnosis, Prevention, and Treatment”, state order no. АААА-А17-117112850280-2, state assignment no. 0324-2018-0001 experimental design work (“Erythrocytes”).
Received: 24.12.2018
Revised: 28.01.2019
Accepted: 31.01.2019
English version:
Optics and Spectroscopy, 2019, Volume 126, Issue 5, Pages 568–573
DOI: https://doi.org/10.1134/S0030400X19050163
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: M. V. Kruchinina, Ya. I. Prudnikova, A. A. Gromov, V. M. Generalov, K. V. Generalov, V. N. Kruchinin, E. V. Kruchinina, G. V. Shuvalov, I. N. Yakovina, N. A. Bannova, O. V. Minin, I. V. Minin, “New opportunities for colorectal cancer diagnostics using an optical cell detection system based on dielectrophoresis”, Optics and Spectroscopy, 126:5 (2019), 650–655; Optics and Spectroscopy, 126:5 (2019), 568–573
Citation in format AMSBIB
\Bibitem{KruPruGro19}
\by M.~V.~Kruchinina, Ya.~I.~Prudnikova, A.~A.~Gromov, V.~M.~Generalov, K.~V.~Generalov, V.~N.~Kruchinin, E.~V.~Kruchinina, G.~V.~Shuvalov, I.~N.~Yakovina, N.~A.~Bannova, O.~V.~Minin, I.~V.~Minin
\paper New opportunities for colorectal cancer diagnostics using an optical cell detection system based on dielectrophoresis
\jour Optics and Spectroscopy
\yr 2019
\vol 126
\issue 5
\pages 650--655
\mathnet{http://mi.mathnet.ru/os722}
\crossref{https://doi.org/10.21883/OS.2019.05.47666.15-19}
\elib{https://elibrary.ru/item.asp?id=39133879}
\transl
\jour Optics and Spectroscopy
\yr 2019
\vol 126
\issue 5
\pages 568--573
\crossref{https://doi.org/10.1134/S0030400X19050163}
Linking options:
  • https://www.mathnet.ru/eng/os722
  • https://www.mathnet.ru/eng/os/v126/i5/p650
    • This publication is cited in the following 5 articles:
    1. M. V. Kruchinina, A. A. Gromov, E. V. Kruchinina, “Structural and functional changes in erythrocytes associated with the development of thrombosis and disorders of hemostasis”, jour, 18:2 (2022), 165  crossref
    2. Logeeshan Velmanickam, Vidura Jayasooriya, Madhava Sarma Vemuri, Umamaheswara Rao Tida, Dharmakeerthi Nawarathna, “Recent advances in dielectrophoresis toward biomarker detection: A summary of studies published between 2014 and 2021”, Electrophoresis, 43:1-2 (2022), 212  crossref
    3. M. V. Kruchinina, A. A. Gromov, L. V. Shcherbakova, E. V. Kruchinina, V. M. Generalov, K. V. Generalov, V. N. Kruchinin, S. V. Rykhlitskii, I. N. Yakovina, M. V. Yakovlev, O. V. Minin, I. V. Minin, “Electrical and viscoelastic parameters of red blood cells in models for the diagnosis of adenomatous polyps and stages of colorectal cancer with optical detection of cells in non-uniform alternating electric field”, Optics and Spectroscopy, 129:12 (2021), 1327–1340  mathnet  mathnet  crossref  crossref
    4. Margarita V. Kruchinina, Andrey A. Gromov, Vladimir N. Kruchinin, Vladimir M. Generalov, Nazar A. Nikolaev, Valeriy D. Antsygin, Igor V. Minin, Oleg V. Minin, “Investigation of red blood cells from patients with diffuse liver diseases by combined dielectrophoresis and terahertz spectroscopy method”, Opt. Eng., 60:08 (2020)  crossref
    5. M. V. Kruchinina, V. N. Kruchinin, G. V. Shuvalov, I. V. Minin, O. V. Minin, “Nuclear magnetic resonance and infrared spectroscopy examination of blood for diagnosis of the diffuse hepatopathy state”, Optics and Spectroscopy, 128:6 (2020), 787–793  mathnet  mathnet  crossref  crossref
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
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