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Optics and Spectroscopy, 2019, Volume 126, Issue 6, Page 809
DOI: https://doi.org/10.21883/OS.2019.06.47776.56-19
(Mi os696)
 

This article is cited in 1 scientific paper (total in 1 paper)

The 22nd Annual Conference Saratov Fall Meeting 2018 (SFM'18): VI International Symposium ''Optics and Biophotonics'' and XXII International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics
Biophotonics

Solid lipid curcumin-loaded particles for in vivo fluorescent imaging in humans: a proof of concept

M. A. Gogolevaa, B. P. Yakimova, S. A. Rodionovb, T. N. Tikhonovac, Yu. I. Gurfinkeld, V. V. Fadeeva, J. Lademannefg, M. E. Darvinefg, E. A. Shirshina

a Lomonosov Moscow State University, Faculty of Physics, Moscow, Russia
b N.N. Priorov Central Institute for Traumatology and Orthopedics, Moscow, Russia
c International Laser Center, Lomonosov Moscow State University, Moscow, Russia
d Lomonosov Moscow State University Clinic, Moscow, Russia
e Charité - Universitätsmedizin Berlin, Berlin, Germany
f Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Berlin, Germany
g Center of Experimental and Applied Cutaneous Physiology (CCP), Berlin, Germany
Citations (1)
Abstract: The possibility to use oral intake of fluorescent dyes approved on humans for intravital fluorescence in vivo imaging is attractive due to its simplicity and non-invasive character. Here we investigate the potential of solid lipid curcumin particles (SLCP) for imaging of capillary permeability using fluorescence video capillaroscopy. Curcumin fluorescence corresponding to 0.7 $\mu$g/ml concentration was observed from blood plasma after oral consumption of 2 g of SLCP. However, this signal was $\sim$15% higher than that of blood plasma intrinsic fluorescence, which was itself at least 10-fold lower than the background signal from pericapillary tissue. By comparing the optical properties and concentration to the case of intravenous injection of sodium fluorescein, we analyzed which parameters of the experiment should be optimized for using oral consumption of fluorescing compounds in intravital in vivo capillaroscopy measurements.
Funding agency Grant number
Russian Science Foundation 17-75-10215
Russian Foundation for Basic Research 16-32-60168 mol_a_dk
This work was supported by the Russian Science Foundation (grant no. 17-75-10215). The work on in vivo fluorescence microscopy was supported by the Russian Foundation for Basic Research (grant no. 16-32-60168 mol_a_dk).
Received: 15.01.2019
Revised: 20.02.2019
Accepted: 26.02.2019
English version:
Optics and Spectroscopy, 2019, Volume 126, Issue 6, Pages 730–735
DOI: https://doi.org/10.1134/S0030400X19060067
Bibliographic databases:
Document Type: Article
Language: English
Citation: M. A. Gogoleva, B. P. Yakimov, S. A. Rodionov, T. N. Tikhonova, Yu. I. Gurfinkel, V. V. Fadeev, J. Lademann, M. E. Darvin, E. A. Shirshin, “Solid lipid curcumin-loaded particles for in vivo fluorescent imaging in humans: a proof of concept”, Optics and Spectroscopy, 126:6 (2019), 809; Optics and Spectroscopy, 126:6 (2019), 730–735
Citation in format AMSBIB
\Bibitem{GogYakRod19}
\by M.~A.~Gogoleva, B.~P.~Yakimov, S.~A.~Rodionov, T.~N.~Tikhonova, Yu.~I.~Gurfinkel, V.~V.~Fadeev, J.~Lademann, M.~E.~Darvin, E.~A.~Shirshin
\paper Solid lipid curcumin-loaded particles for \emph{in vivo} fluorescent imaging in humans: a proof of concept
\jour Optics and Spectroscopy
\yr 2019
\vol 126
\issue 6
\pages 809
\mathnet{http://mi.mathnet.ru/os696}
\crossref{https://doi.org/10.21883/OS.2019.06.47776.56-19}
\elib{https://elibrary.ru/item.asp?id=41130930}
\transl
\jour Optics and Spectroscopy
\yr 2019
\vol 126
\issue 6
\pages 730--735
\crossref{https://doi.org/10.1134/S0030400X19060067}
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  • This publication is cited in the following 1 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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