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Optics and Spectroscopy, 2019, Volume 127, Issue 6, Pages 917–925
DOI: https://doi.org/10.21883/OS.2019.12.48686.159-19
(Mi os517)
 

This article is cited in 3 scientific papers (total in 3 papers)

Spectroscopy of condensed matter

A spectroscopic study of changes in the secondary structure of proteins of biological fluids of the oral cavity by synchrotron infrared microscopy

P. V. Seredina, D. L. Goloshchapova, Yu. A. Ippolitovb, Jitraporn(Pimm) Vongsvivutc

a Voronezh State University, 394036, Voronezh, Russia
b Burdenko Voronezh State Medical University, 394036, Voronezh, Russia
c Australian Synchrotron (Synchrotron Light Source Australia Pty LTD), VIC 3168, Australia
Citations (3)
Abstract: On the basis of the data of infrared spectroscopy with synchrotron radiation, the secondary structure of proteins of the dentinal and gingival fluids during the development of cariosity in deep dentin tissues is studied. It is shown that the change in the shape of the profile of the amide I band in the region of 1700–1605 cm$^{-1}$ is associated both with a change in the ratio of the integrated absorption intensities of the $\alpha$-helix and $\beta$-sheet secondary structures and with the position of the $\beta$-coil and $\beta$-sheet components in the spectrum. It is established that the $\alpha$-helix/$\beta$-sheet ratio for both dentinal and gingival fluids is below the threshold level, at which significant changes in the secondary structure of proteins of biological fluids are observed, unequivocally indicating the development of pathology in hard dental tissues. The features that we discovered in the profile of the amide I band of biological fluids of the oral cavity, together with the spectral markers of the development of cariosity in dentin, are reliable spectroscopic signatures of the pathology and can be detected using the gingival fluid.
Keywords: IR microscopy, synchrotron radiation, dentin caries, spectroscopic signatures of pathological processes.
Funding agency Grant number
Russian Science Foundation 16-15-00003
This study was supported by a grant from the Russian Science Foundation, project no. 16-15-00003.
Received: 14.05.2019
Revised: 24.07.2019
Accepted: 12.08.2019
English version:
Optics and Spectroscopy, 2019, Volume 127, Issue 6, Pages 1002–1010
DOI: https://doi.org/10.1134/S0030400X19120221
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: P. V. Seredin, D. L. Goloshchapov, Yu. A. Ippolitov, Jitraporn(Pimm) Vongsvivut, “A spectroscopic study of changes in the secondary structure of proteins of biological fluids of the oral cavity by synchrotron infrared microscopy”, Optics and Spectroscopy, 127:6 (2019), 917–925; Optics and Spectroscopy, 127:6 (2019), 1002–1010
Citation in format AMSBIB
\Bibitem{SerGolIpp19}
\by P.~V.~Seredin, D.~L.~Goloshchapov, Yu.~A.~Ippolitov, Jitraporn(Pimm)~Vongsvivut
\paper A spectroscopic study of changes in the secondary structure of proteins of biological fluids of the oral cavity by synchrotron infrared microscopy
\jour Optics and Spectroscopy
\yr 2019
\vol 127
\issue 6
\pages 917--925
\mathnet{http://mi.mathnet.ru/os517}
\crossref{https://doi.org/10.21883/OS.2019.12.48686.159-19}
\elib{https://elibrary.ru/item.asp?id=42571240}
\transl
\jour Optics and Spectroscopy
\yr 2019
\vol 127
\issue 6
\pages 1002--1010
\crossref{https://doi.org/10.1134/S0030400X19120221}
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  • https://www.mathnet.ru/eng/os/v127/i6/p917
  • This publication is cited in the following 3 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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