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Optics and Spectroscopy, 2020, Volume 128, Issue 7, Pages 956–963
DOI: https://doi.org/10.21883/OS.2020.07.49568.73-20 (Mi os373) 		 
This article is cited in 9 scientific papers (total in 9 papers)

Biophotonics

Study of blood serum in rats with transplanted cholangiocarcinoma using Raman spectroscopy

A. A. Man'kovaa, O. P. Cherkasovabc, E. N. Lazarevade, A. B. Bucharskayaf, P. A. Dyachenkode, Yu. V. Kisteneveg, D. A. Vrazhnoveh, V. E. Skibae, V. V. Tuchinedi, A. P. Shkurinovab

a Lomonosov Moscow State University
b Institute on Laser and Information Technologies, Russian Academy of Scienses, Shatura, Moskovskaya obl.
c Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk
d Saratov State University
e Tomsk State University
f Saratov State Medical University named after V. I. Razumovsky
g Siberian State Medical University
h Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences, Tomsk, Russia
i Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov
Full-text PDF (1189 kB) Citations (9)
DOI: https://doi.org/10.21883/OS.2020.07.49568.73-20
Abstract: Serum samples of healthy rats and rats with inoculated tumors on days 14 and 28 after transplantation of cholangiocarcinoma cells were analyzed using Raman spectroscopy (RS). It was shown that the intensity of the amide 1 band differs in the serum spectra depending on the stage of tumor development and correlates with the protein concentration in the samples. In some animals, there is a significant increase in the blood glucose concentration, leading to glycation of proteins and a change in the shape of the amide 1 band. The appearance of a band at 1670 cm$^{-1}$ is most pronounced in the spectra of samples on the 28th day of the experiment and may be associated with an increase in the content of $\beta$-structural elements in the protein conformation. Using the principal component analysis, we assessed the general differences in the Raman spectra of the blood serum in rats of control groups and rats on the 28th day after tumor transplantation.
Keywords: Raman spectroscopy, blood serum, experimental liver cancer, principal component analysis.
Funding agency Grant number
Russian Foundation for Basic Research 17-00-00275
17-00-00270
17-00-00186
17-00-00272
19-52-55004
Program of fundamental scientific research of the State Academies of Sciences III.23.2.10
This study was supported in part by the Russian Foundation for Basic Research, projects no 17-00-00275 (17-00-00270, 17-00-00186, and 17-00-00272) and 19-52-55004, as well as by the Ministry of Science and Higher Education within the State assignment FSRC “Crystallography and Photonics” RAS. The work was performed under the Go-vernment Statement of work for ISPMS project no. III.23.2.10.
Received: 10.01.2020
Revised: 31.01.2020
Accepted: 28.02.2020
English version:
Optics and Spectroscopy, 2020, Volume 128, Issue 7, Pages 964–971
DOI: https://doi.org/10.1134/S0030400X20070115
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: A. A. Man'kova, O. P. Cherkasova, E. N. Lazareva, A. B. Bucharskaya, P. A. Dyachenko, Yu. V. Kistenev, D. A. Vrazhnov, V. E. Skiba, V. V. Tuchin, A. P. Shkurinov, “Study of blood serum in rats with transplanted cholangiocarcinoma using Raman spectroscopy”, Optics and Spectroscopy, 128:7 (2020), 956–963; Optics and Spectroscopy, 128:7 (2020), 964–971
Citation in format AMSBIB
\Bibitem{ManCheLaz20}
\by A.~A.~Man'kova, O.~P.~Cherkasova, E.~N.~Lazareva, A.~B.~Bucharskaya, P.~A.~Dyachenko, Yu.~V.~Kistenev, D.~A.~Vrazhnov, V.~E.~Skiba, V.~V.~Tuchin, A.~P.~Shkurinov
\paper Study of blood serum in rats with transplanted cholangiocarcinoma using Raman spectroscopy
\jour Optics and Spectroscopy
\yr 2020
\vol 128
\issue 7
\pages 956--963
\mathnet{http://mi.mathnet.ru/os373}
\crossref{https://doi.org/10.21883/OS.2020.07.49568.73-20}
\elib{https://elibrary.ru/item.asp?id=43870288}
\transl
\jour Optics and Spectroscopy
\yr 2020
\vol 128
\issue 7
\pages 964--971
\crossref{https://doi.org/10.1134/S0030400X20070115}
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