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Optics and Spectroscopy, 2020, Volume 128, Issue 7, Pages 950–955
DOI: https://doi.org/10.21883/OS.2020.07.49567.63-20 (Mi os372) 		 
This article is cited in 11 scientific papers (total in 11 papers)

Biophotonics

Laser correlation spectrometer for assessing the size and dynamics of changes in the size of structures in biological fluids

E. N. Velichkoa, È. K. Nepomnyashchayaa, A. V. Sokolovb, T. Yu. Kudryashovaa

a Peter the Great St. Petersburg Polytechnic University
b CSRI Elektropribor, St. Petersburg
Full-text PDF (533 kB) Citations (11)
DOI: https://doi.org/10.21883/OS.2020.07.49567.63-20
Abstract: To estimate the size of nanostructures in biological fluids and study the dynamics of their change, a modified method of laser correlation spectroscopy is proposed. The scheme of the hardware-software complex and the algorithm of the method are described, which allows one to achieve high accuracy in determining the size of nanoparticles, as well as to study the process of changing the size of nanoparticles in dynamics. The proposed hardware-software complex made it possible to study the dynamics of the formation of aggregates in human serum in the process of immune response. The results obtained indicate the presence of processes of rapid protein aggregation as a result of activation of the immune response. In addition, the size of the aggregates formed depends on the state of the immune system and the presence of diseases.
Keywords: laser correlation spectroscopy, dynamic light scattering, particle sizes, nanoparticles, biological fluid, molecular aggregation.
Received: 10.12.2019
Revised: 03.02.2020
Accepted: 28.02.2020
English version:
Optics and Spectroscopy, 2020, Volume 128, Issue 7, Pages 959–963
DOI: https://doi.org/10.1134/S0030400X20070255
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: E. N. Velichko, È. K. Nepomnyashchaya, A. V. Sokolov, T. Yu. Kudryashova, “Laser correlation spectrometer for assessing the size and dynamics of changes in the size of structures in biological fluids”, Optics and Spectroscopy, 128:7 (2020), 950–955; Optics and Spectroscopy, 128:7 (2020), 959–963
Citation in format AMSBIB
\Bibitem{VelNepSok20}
\by E.~N.~Velichko, \`E.~K.~Nepomnyashchaya, A.~V.~Sokolov, T.~Yu.~Kudryashova
\paper Laser correlation spectrometer for assessing the size and dynamics of changes in the size of structures in biological fluids
\jour Optics and Spectroscopy
\yr 2020
\vol 128
\issue 7
\pages 950--955
\mathnet{http://mi.mathnet.ru/os372}
\crossref{https://doi.org/10.21883/OS.2020.07.49567.63-20}
\elib{https://elibrary.ru/item.asp?id=43870287}
\transl
\jour Optics and Spectroscopy
\yr 2020
\vol 128
\issue 7
\pages 959--963
\crossref{https://doi.org/10.1134/S0030400X20070255}
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  • https://www.mathnet.ru/eng/os/v128/i7/p950
    • This publication is cited in the following 11 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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