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Optics and Spectroscopy, 2021, Volume 129, Issue 6, Pages 711–716
DOI: https://doi.org/10.21883/OS.2021.06.50981.11-21
(Mi os114)
 

Proceedings of the international conference ''The XXIV Annual Conference Saratov Fall Meeting 2020''
Biophotonics

The platelet functional activity modification under prolonged light exposure in the experiment

O. V. Zlobina, V. F. Kirichuk, S. S. Pakhomy, A. N. Ivanov, A. Yu. Karetnikova, E. S. Terekhina, N. V. Shlyapnikov, I. O. Bugaeva

Saratov State Medical University named after V. I. Razumovsky
Abstract: We studied the effect of intensive light exposure on the aggregation activity of white male rats' platelets using the experimental Light-Dark (18:6) lighting model. Analysis of platelet aggregation activity was carried out using a computerized 230LA “Biola” aggregation analyzer using the method of V.A. Gabbasov. It was established that in case of prolonged light exposure in the body of laboratory animals there was a disturbance of aggregation activity accompanied by an increase in the parameters of the curve of the average weighted radius of platelets and the parameters of the light transmittance curve. Violation of the daytime regime in the form of artificial prolongation of illumination causes increase of platelet aggregation activity and provokes development of microcirculatory disturbances. Forming changes in the hemostasis system increase in proportion to the duration of the experiment. The most pronounced changes in the vascular-platelet mechanism of hemostasis are formed on the 21st day of the experiment, indicating the development of processes of maladaptation followed by exhaustion of the organism.
Keywords: platelet aggregation, circadian rhythms, light exposure, photoperiodism disorders, microcirculatory disorders.
Funding agency Grant number
Ministry of Science and Higher Education of the Russian Federation
This work was performed as part of the project “Development of a mathematical model to assess the rate at which functional changes in the body due to light-induced desynchronosis transform into irreversible morphological changes in the target organs in a simulation experiment” according to the State Assignment to the Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation.
Received: 30.12.2020
Revised: 03.02.2021
Accepted: 26.02.2021
English version:
Optics and Spectroscopy, 2021, Volume 129, Issue 8, Pages 861–866
DOI: https://doi.org/10.1134/S0030400X21060217
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: O. V. Zlobina, V. F. Kirichuk, S. S. Pakhomy, A. N. Ivanov, A. Yu. Karetnikova, E. S. Terekhina, N. V. Shlyapnikov, I. O. Bugaeva, “The platelet functional activity modification under prolonged light exposure in the experiment”, Optics and Spectroscopy, 129:6 (2021), 711–716; Optics and Spectroscopy, 129:8 (2021), 861–866
Citation in format AMSBIB
\Bibitem{ZloKirPak21}
\by O.~V.~Zlobina, V.~F.~Kirichuk, S.~S.~Pakhomy, A.~N.~Ivanov, A.~Yu.~Karetnikova, E.~S.~Terekhina, N.~V.~Shlyapnikov, I.~O.~Bugaeva
\paper The platelet functional activity modification under prolonged light exposure in the experiment
\jour Optics and Spectroscopy
\yr 2021
\vol 129
\issue 6
\pages 711--716
\mathnet{http://mi.mathnet.ru/os114}
\crossref{https://doi.org/10.21883/OS.2021.06.50981.11-21}
\elib{https://elibrary.ru/item.asp?id=46489746}
\transl
\jour Optics and Spectroscopy
\yr 2021
\vol 129
\issue 8
\pages 861--866
\crossref{https://doi.org/10.1134/S0030400X21060217}
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