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This article is cited in 4 scientific papers (total in 4 papers)
Proceedings of the international conference ''The XXIV Annual Conference Saratov Fall Meeting 2020''
Biophotonics
Spectroscopic study of the release kinetics of water-insoluble drug griseofulvin from vaterite containers in aqueous medium
M. S. Savelyevaa, E. V. Lengerta, A. M. Abramovab, S. N. Shtykovb, Yu. I. Svenskayaa a Educational-Research Institute of Nanostructures and Biosystems of Saratov State University
b N. G. Chernyshevskii Saratov State University, Institute of Chemistry
Abstract:
The bioavailability improvement of hydrophobic drugs is one of the major problems in pharmaceutical research as required for the enhancement of their therapeutic efficacy. Encapsulation of such drugs into various micro- and nanocarriers enabling the targeted delivery represents an important strategy here. The process of the designed nanoformulation study generally includes characterization of the payload release profile in model water-based media, which provides a challenge to encapsulated hydrophobic drugs due to their poor solubility in water. Thus, modification of the existed release investigation protocols is required for reliable detection of the liberated hydrophobic drug. Here, we report an optimized multimodal spectroscopic and microscopic study of the release behaviour of griseofulvin (Gf), a water-insoluble antifungal drug, from vaterite carriers. The addition of N, N-dimethylformamide (DMF), a polar aprotic solvent, to aqueous suspensions of Gf-loaded vaterite carriers at the investigated time points right before the UV-Vis spectroscopic measurement allowed us to enhance the accuracy of the released Gf determination. Monitoring of the carrier degradation process by a combination of scanning electron microscopy and Raman spectroscopy demonstrated a good correlation between the obtained data and the payload release kinetics.
Keywords:
UV-Vis spectroscopy, Raman spectroscopy, targeted drug delivery, vaterite carriers, antifungal drug, release kinetics.
Received: 07.12.2020 Revised: 06.01.2021 Accepted: 26.02.2021
Citation:
M. S. Savelyeva, E. V. Lengert, A. M. Abramova, S. N. Shtykov, Yu. I. Svenskaya, “Spectroscopic study of the release kinetics of water-insoluble drug griseofulvin from vaterite containers in aqueous medium”, Optics and Spectroscopy, 129:6 (2021), 669–676; Optics and Spectroscopy, 129:7 (2021), 813–820
Linking options:
https://www.mathnet.ru/eng/os109 https://www.mathnet.ru/eng/os/v129/i6/p669
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