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Nanosystems: Physics, Chemistry, Mathematics, 2017, Volume 8, Issue 4, Pages 531–534
DOI: https://doi.org/10.17586/2220-8054-2017-8-4-531-534 (Mi nano70) 		 
This article is cited in 4 scientific papers (total in 4 papers)

CHEMISTRY AND MATERIAL SCIENCE

Antibacterial activity of Amikacin-immobilized detonation nanodiamond

A. S. Solomatinab, R. Yu. Yakovlevabc, O. V. Efremenkovad, I. G. Sumarukovad, I. I. Kulakovab, G. V. Lisichkinb

a Ryazan State Medical University, Ryazan, Russia
b Lomonosov Moscow State University
c Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow
d Gause Institute of New Antibiotics, Moscow, Russia
Full-text PDF (122 kB) Citations (4)
DOI: https://doi.org/10.17586/2220-8054-2017-8-4-531-534
Abstract: Detonation nanodiamonds (NDs) with chlorinated (ND-Cl) and carboxylated (ND-COOH) surfaces were obtained. The broad-spectrum antibiotic Amikacin (Amik) was covalently grafted to the chlorinated surface (ND-Amik) and immobilized by adsorption to carboxylated surface (Amik/ND-COOH). Biological testing in vitro showed the presence of antibacterial activity of the obtained samples against Staphylococcus aureus FDA P209 and Escherichia coli ATCC 25922, close to activity of free amikacin. It was revealed that to maintain antibacterial activity of the samples after their preliminary treatment, important factors such as the use of antioxidants (hydrosulfite and sodium citrate) and lyophilization were necessary.
Keywords: detonation nanodiamond (ND), amikacin (Amik), lyophilization, antioxidants, antibacterial activity.
Funding agency Grant number
Russian Foundation for Basic Research 16-08-01156
This study has been performed with support from the grant of Russian Science Foundation (project 16-08-01156).
Received: 27.05.2017
Revised: 03.07.2017
Bibliographic databases:
Document Type: Article
PACS: 68.35.-p, 7.85.Tu
Language: English
Citation: A. S. Solomatin, R. Yu. Yakovlev, O. V. Efremenkova, I. G. Sumarukova, I. I. Kulakova, G. V. Lisichkin, “Antibacterial activity of Amikacin-immobilized detonation nanodiamond”, Nanosystems: Physics, Chemistry, Mathematics, 8:4 (2017), 531–534
Citation in format AMSBIB
\Bibitem{SolYakEfr17}
\by A.~S.~Solomatin, R.~Yu.~Yakovlev, O.~V.~Efremenkova, I.~G.~Sumarukova, I.~I.~Kulakova, G.~V.~Lisichkin
\paper Antibacterial activity of Amikacin-immobilized detonation nanodiamond
\jour Nanosystems: Physics, Chemistry, Mathematics
\yr 2017
\vol 8
\issue 4
\pages 531--534
\mathnet{http://mi.mathnet.ru/nano70}
\crossref{https://doi.org/10.17586/2220-8054-2017-8-4-531-534}
\isi{https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Publons&SrcAuth=Publons_CEL&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=000412772800015}
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    • This publication is cited in the following 4 articles:
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